1. Prevention of HPV subtypes
Whether it is an imported or domestic bivalent HPV vaccine, the subtypes it prevents are HPV16 and HPV18;
2 models HPV vaccines are all approved to prevent cervical cancer and cervical cancer in situ caused by infection with HPV16 and 18.
The instructions for the imported bivalent HPV vaccine mention that it is effective against HPV31/33 and 45 has a cross-protective effect, but there is no evidence that it can prevent related diseases caused by several HPV subtypes
2. Antibody persistence
Persistence of antibodies to HPV16 and HPV18 There is not much difference between the two vaccines;
Among them, the HPV16 antibody positivity rate of Chinese-made Xinconin can reach 100% at 66 months after vaccination, while the imported Cervarix can reach 100% at 60 months after vaccination. The positive rate of HPV16 in the first month was also 100%, and dropped to 99.6% in the 72nd month.
In terms of the persistence of HPV18 antibodies, the domestic Xinconin was 98.3% after the 42nd month, and the imported Xinconin was 98.3% after the 42nd month. Reshi was 99.3% 48 months after vaccination;
Because the age groups of the sample data and the time of taking the values ??are different, the data will be slightly different~
If it seems to be more troublesome for everyone Boy, let me summarize for you: the two are basically the same in terms of antibody concentration and persistence of HPV16 and 18 types;
3. Other comparisons
Expression system:
p>The two bivalent HPV vaccines are both recombinant human papillomavirus vaccines. Cervarix uses an insect cell expression system, while Xingonin uses an Escherichia coli expression system, which has high production capacity and low cost. Lower price;
Characteristics:
Domestic 2-price is vial packaging, imported 2-price is pre-filled packaging:
Generally speaking, imported 2-price is There is little overall difference with the domestic bivalent HPV vaccine.
4. Price analysis
The price of domestic Xinconin is about 350 yuan per shot, and the imported Xinconin is about 605 yuan per shot. Therefore, relatively speaking, the price of domestically produced 2 The price/performance ratio will be higher.
It is recommended that no matter which vaccine you choose, the sooner you get vaccinated, the earlier you will be protected, and the higher the cost-effectiveness.