Pharmacological experiments show that dihydromyricetin has antibacterial effects on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, aerogenes, Saccharomyces cerevisiae, Rhodotorula glutinosa, Penicillium, Aspergillus niger, Aspergillus flavus, Mucor and Rhizopus, especially on Gram-positive and Gram-negative cocci or bacilli.
2. Regulation of blood sugar and blood lipid.
Pharmacological experiments of gastric perfusion in mice showed that dihydromyricetin could significantly inhibit the increase of blood sugar induced by alloxan, epinephrine and streptozotocin in mice, at the same time, increase the serum insulin level, significantly reduce the infiltration of lymphocytes in pancreatic tissue, significantly reduce inflammatory reaction and significantly increase the number of islets.
Dihydromyricetin can reduce the content of serum triglyceride in streptozotocin-induced hyperglycemia rats, but has no obvious effect on the content of serum total cholesterol and high density lipoprotein cholesterol.
3. Liver protection
Dihydromyricetin has obvious protective effects on the toxic injury of rat hepatocytes induced by carbon tetrachloride in vitro and the liver injury induced by D2 galactosamine and lipopolysaccharide in mice. Dihydromyricetin can protect the liver, accelerate the rapid decomposition of acetaldehyde, a metabolite of ethanol, and turn it into a non-toxic substance, thus reducing its damage to liver cells.
In addition, dihydromyricetin can improve the increase of serum lactate dehydrogenase activity caused by hepatocyte injury and inhibit the formation of collagen fibers in liver M cells, thus playing a role in protecting the liver, greatly reducing the damage of ethanol to the liver and making the liver return to normal quickly.
Microherb test proved that dihydromyricetin can protect the liver, accelerate the rapid decomposition of acetaldehyde, a metabolite of ethanol, and turn it into a non-toxic substance, thus reducing the damage to liver cells. Dihydromyricetin takes effect quickly and lasts for a long time, which is a good product for protecting liver and relieving alcoholism.
4. Antioxidant effect
Dihydromyricetin with purity of 98% can obviously inhibit the production of malondialdehyde in rat heart, liver and brain homogenate, and its inhibition is enhanced with the increase of dihydromyricetin concentration. The scavenging rate of dihydromyricetin (99%) on DPPH radical in the experimental system.
Dihydromyricetin can obviously inhibit the production of MDA in oil, and its antioxidant effect is enhanced with the increase of the purity of dihydromyricetin (60% ~ 90%). It has a strong antioxidant effect on animal oil and vegetable oil.
5. Antitumor effect
In recent years, ampelopsin, one of its active components, has been found to have a strong anticancer effect. Anti-tumor studies in vitro and in vivo show that the compound can improve the therapeutic effect of tumor and biological diseases of patients by inhibiting the growth of tumor blood vessels, regulating and enhancing cellular immune function.
It shows obvious anti-tumor effect in tumor model experiments such as leukemia and nasopharyngeal carcinoma.
Extended data synthesis method
(1) Add solid sodium hydroxide into a stirring tank, add water while stirring to prepare a solution of about 160g/L, then add hexachlorobenzene into the alkali liquor according to the molar ratio of hexachlorobenzene to sodium hydroxide 1: (2.5 ~ 2.6) while stirring, and pump it into a high-pressure hydrolysis kettle after stirring.
(2) When the stirring temperature rises to 2.0MPa, stop heating. Due to the exothermic reaction, the temperature in the reaction kettle will automatically rise to 230℃, the pressure in the kettle will reach 2.55MPa, and the hydrolysis will be completed after holding at 230℃ for 20 minutes. Then discharging under pressure, cooling and crystallizing, and filtering to obtain scaly solid sodium pentachlorophenol; ?
(3) adding sodium pentachlorophenol into the reaction kettle, adding 3 1% hydrochloric acid under stirring for acidification, and keeping the acidification temperature at 80-90 DEG C.. After acidification, the product was washed, filtered and dried to obtain the product.
References:
Baidu encyclopedia-dihydromyricetin