Maitake is a kind of mushroom, which mainly grows in Japan, China’s Zhejiang, Fujian, Yunnan, and Southeast Asia. It is also called Maitake; maitake is the English name of Maitake; in 1985, Japan Professor Hiraki Namba of Kobe Pharmaceutical University was influenced by the anti-cancer effect of lentinan and extracted effective Maitake polysaccharide component from Maitake mushroom. The D component has a very good anti-cancer effect. Therefore, it was first used as D- Fraction, or Maitake D-Fraction, was commonly used in articles before 2002. At that time, there was a lack of awareness of patent protection, and some manufacturers used Polyporus polysaccharides to extract polysaccharide components that are similar in structure to Maitake mushrooms. Therefore, D-Fraction is also used, or even named after Maitake D-Fraction. However, although the two are similar, the D-Fraction related articles published in all core journals use the raw materials and patents provided by Professor Hiroaki Namba. As a result, Professor Hiraki Namba specially registered the MD-Fraction trademark (M is the abbreviation of maitake, which stands for Maitake). Therefore, when purchasing products, look for MD-Fraction and VERDAD (Vertex Co., Ltd. Company trademark) logo. When reading the literature, please pay attention to the author. In any article with HIROAKI NANBA, all products used specifically refer to products currently marked with MD-Fraction and VERDAD (trademark of Vertex Corporation).