Basic information column
Name: CECT57 16
Type: Lactobacillus of Lactobacillus family, Lactobacillus order.
Function: Effective prevention and treatment of acute, subacute and recessive mastitis; Reduce the probability of infectious diseases; Prevention and treatment of neonatal allergic eczema: promoting intestinal digestion and absorption, protecting gastrointestinal health; Enhance human immunity and so on.
main body
brief introduction
CECT57 16, that is, Lactobacillus fermentum CECT57 16, is a beneficial bacterium isolated from healthy breast milk, which is more acceptable to human body and is known as the "aristocrat" among probiotics.
In the last century, it was generally believed that the breast milk of healthy people was sterile and did not contain microorganisms. Later, a high-tech biotechnology listed company in Spain, Biosearch Life, found through clinical research that there are microorganisms such as lactic acid bacteria in breast milk, which colonize the intestines of newborns through breastfeeding. After a comprehensive screening procedure including safety and effectiveness indicators, Biosearch Life screened and isolated Lactobacillus fermentum CECT 57 16 from human milk. This strain naturally exists in human breast milk and has excellent probiotic characteristics. After strain identification, functional verification and safety evaluation, it is the first breast milk probiotic in the world.
CECT57 16 can effectively prevent and treat acute, subacute and recessive mastitis. Reduce the probability of infectious diseases; Prevention and treatment of neonatal allergic eczema: promoting intestinal digestion and absorption, protecting gastrointestinal health; Enhance human immunity and so on. It's good for pregnant women and babies.
cognitive process
1, research background
As we all know, breast milk is the best food for babies, because it provides all the nutrients that babies need for rapid growth. In addition, many studies show that breastfeeding can prevent babies from being infected by many diseases. This effect may be the result of the comprehensive effect of various components in breast milk.
In the twentieth century, it was generally believed that the fetus was sterile in the uterus, and the colonization of intestinal flora in newborns began when the baby passed through the birth canal at birth. During this birth process, the flora of vagina and excrement is transferred from mother to newborn through cross infection.
However, the detection results of the flora of caesarean section newborns show that the fecal microbial flora is very similar to that of natural newborns. This result excludes the previous hypothesis.
Biosearch Life confirmed the existence of flora in meconium (the first excretion of newborn) and umbilical cord blood. This shows that probiotics are passed from mother to newborn during pregnancy. After in-depth research, Biosearch Life later proved that there are bacteria in breast milk and that it will be passed on to newborns through the natural process of maternal breastfeeding. Breast milk plays an important role in the establishment and proliferation of intestinal flora of breast-fed newborns, and is a continuous source of lactic acid bacteria in infants' intestines.
2. Cognitive process
① In 1990s, some bacterial strains were found in human breast milk, but they were considered to be related to "potential pollution".
② In 2000, Spanish scientists isolated a series of microbial strains beneficial to human body from human milk, and found that this strain can improve the immunity and intestinal health of infants.
③ The first paper on the physiological existence of microorganisms in breast milk was published in 2003.
④ In 2006, clinical research confirmed that Lactobacillus fermentum CECT57 16 derived from breast milk had a good therapeutic effect on lactation mastitis.
⑥20 1 1 year, Lactobacillus fermentum was listed in the list of food available bacteria in China.
⑦ In 2065438+06, with the approval of China Municipal Health Planning Commission, Lactobacillus fermentum CECT57 16 was listed in the list of bacteria used in infant food, and it was also the only probiotic isolated from healthy breast milk.
Certification honor
1, obtained WIPO patent.
Lactobacillus fermentum CECT57 16 has obtained WIPO patent certification with patent number WO/2004/003235.
2. Obtain the double certification of EFSA and FDA/GRAS.
EFSA European food safety agency certification
Lactobacillus fermentum CECT57 16 is currently listed as QPS by the European Food Safety Agency (EFSA). Any kind of microorganism can clearly determine its species. Once designated as QSP, it means that there is no need for further safety assessment of microbial strains except for specific identification.
FDA/GRAS certification
Lactobacillus fermentum CECT57 16 has been certified by the US Food and Drug Administration and confirmed as a safe strain by GRAS.
3. Obtained the quality certification of China.
CIQ proof
People's Republic of China (PRC) Entry-Exit Goods Inspection and Quarantine Certificate is an official inspection and quarantine certificate provided by AQSIQ after entry-exit goods inspection and quarantine, management and certification.
China Ministry of Health stipulates that it can be used for infant food.
On June 20 16, the Ministry of Health of China listed Lactobacillus fermentum CECT57 16 in the list of bacteria available for infant food.
Excellent efficacy
1, strong growth, super tolerance
Lactobacillus fermentum CECT57 16 can survive in most gastrointestinal conditions and can attach well to intestinal mucosal cells. Therefore, Lactobacillus fermentum CECT57 16 can colonize effectively in human intestine.
2. Effectively relieve mastitis during lactation and protect women's breast health.
Lactobacillus fermentum CECT57 16 can colonize the breast, grow into a dominant flora through competition and secrete a variety of antibacterial substances, which can effectively prevent and treat mastitis, especially lactation mastitis.
3. Strengthen the immune system and prevent disease infection.
Lactobacillus fermentum CECT57 16 can enhance human immune response to influenza vaccine, promote Th 1 immune response and neutralize antibodies in virus, thus enhancing immune system and preventing infection of diseases.
4. Produce short-chain fatty acids, promote intestinal absorption and protect gastrointestinal health.
Lactobacillus fermentum CECT57 16 can ferment a variety of carbohydrates in the intestine and produce short-chain fatty acids (SCFAs), which provides an important energy source for intestinal cells. Short-chain fatty acids can promote intestinal absorption of water and salt, actively participate in the metabolism of colonic epithelial cells, and lower pH value. Propionic acid and acetic acid are transmitted as energy to different organs and tissues, such as muscle, brain and heart. At the same time, butyric acid provides 50% of the daily energy required by gastrointestinal mucosa. In addition, butyric acid protects gastrointestinal cells and inhibits the malignant growth and variation of cells, thus playing a role in preventing colon cancer.
5. Promote the production of mucin and establish the first protective barrier of intestinal epithelial tissue.
Lactobacillus fermentum CECT57 16 can induce mucin production, thus protecting intestinal epithelial cells from physical, chemical and bacterial substances. Mucin in gastrointestinal tract is a glycoprotein expressed by circular cells. Mucin plays a very important role in intestinal protection, which can prevent food and pathogenic bacteria from attaching to intestinal epidermal cells and causing wear. Gastrointestinal mucin can also specifically bind pathogenic bacteria and reduce the number of binding between pathogenic bacteria and intestinal receptor cells, thus effectively preventing the adhesion of pathogenic bacteria to intestinal mucosa.
6. Fermented Lactobacillus CECT57 16 can produce glutathione, which is a natural antioxidant and can protect the intestine from oxidation.
7. Produce antibacterial substances, inhibit harmful bacteria and prevent various infectious diseases.
Lactobacillus fermentum CECT57 16 can produce antibacterial substances and inhibit pathogenic bacteria, such as Escherichia coli, Salmonella, Listeria, Staphylococcus aureus and so on. These antibacterial compounds, including organic acids, hydrogen peroxide and bacteriocin, can reduce the viability of pathogenic bacteria, change their metabolic pathways and interfere with the production of toxins.
Lactobacillus fermentum CECT57 16 can produce a large amount of lactic acid, thus effectively reducing the pH value in the intestine, and further inhibiting the growth and reproduction of pathogenic bacteria in the intestine.
Lactobacillus fermentum CECT57 16 can also increase the permeability of the cell membrane of Gram-negative bacteria, thus reducing its activity, and can also improve the antibacterial effect of other antibacterial compounds.
8. Prevent pathogenic bacteria from reaching intestinal mucosa and protect intestinal health.
Lactobacillus fermentum CECT57 16 prevents pathogenic bacteria from attaching to intestinal mucosa, which is beneficial to eliminate these pathogenic bacteria through excretion. Once the pathogen reaches the intestinal mucosa, its adhesion to the host extracellular matrix complex becomes a prerequisite for the colonization and invasion of epithelial tissues, because it cannot be quickly removed from the intestine. At this time, Lactobacillus fermentum CECT57 16 can combine with these intestinal pathogens to form * * * aggregates, which prevent the pathogens from reaching the intestinal mucosa, and at the same time make the pathogens adhere to mucin to prevent them from invading the intestinal epithelial tissue.
Applicable people
Suitable for everyone, especially:
1, pregnant women; It can help pregnant women to relieve symptoms such as early pregnancy reaction and constipation during pregnancy.
2. Breast-feeding mastitis patients: can effectively relieve mastitis, relieve symptoms such as redness, swelling and pain of female breasts, and protect the health of female breasts.
3, baby: can relieve allergic eczema in newborns, help newborns build their own immune system, enhance the baby's resistance and protect the baby's intestinal health.
4, people with weak gastrointestinal function: can promote intestinal digestion, maintain the balance of intestinal flora, and relieve symptoms such as diarrhea and constipation.