1, paciclovir is an antiviral drug, which was developed in Pfizer and can be used to treat COVID-19 virus infection. The drug consists of two components: nematvir and ritonavir. Among them, nematvir can block the activity of enzymes needed for COVID-19 replication.
2. Ritonavir can slow down the metabolism of nemativir, thus achieving the effect of slowing down the replication of COVID-19 in vivo. In China, Pakslovid is usually translated into Paxlovid, and the name Naimatwe/Litonave is also used in some places.
1, paciclovir is the trade name of COVID-19 oral drug nematevir/ritonavir developed in Pfizer, USA. This product is an oral small molecule COVID-19 therapeutic drug, which is used to treat adult patients with mild to moderate novel coronavirus (coronavirus pneumonia-19). These patients have high risk factors for developing serious diseases, such as the elderly, chronic kidney disease, diabetes, cardiovascular disease, chronic lung disease and other serious high risk factors.
2, 2002165438+February 14 news, Pfizer said that the final analysis still showed that its COVID-19 oral drug paciclovir had 89% effect in preventing hospitalization and death of high-risk patients; 202165438+On February 22nd, the US Food and Drug Administration approved Paxlovid；;
3. On June 2, 2022, local time, German Federal Minister of Health Lauterbach announced that the German federal government hoped to urgently approve COVID-19's oral drug "Paciclovir" in June+10, 5438. On April 2, 2022, Kloc-0, WHO approved the use of COVID-19 oral drug paciclovir produced in Pfizer in high-risk COVID-19 patients.
4. On May 25th, 2023, the drug was officially authorized for emergency use by the US Food and Drug Administration (FDA).
I. Azvudine
1, Afuddin, also known as Afuddin, was invented by Professor Chang Junbiao and jointly developed by Henan Ruier Biotechnology Co., Ltd., Zhengzhou University, Henan Normal University and High-tech Research Center of Henan Academy of Sciences. It is an HIV reverse transcriptase (RT) inhibitor, which belongs to the world's advanced and domestic first-generation drug for treating AIDS.
2. In February, 2020, afudin was found to be anti-COVID-19, and in April, 2020, it was approved by the State Medical Products Administration to carry out anti-COVID-19 Phase III clinical trial. In July, 20021,the anti-HIV drug Afuddin was approved for marketing, which is the first innovative dual-target anti-AIDS drug in the world.
3. On July 25th, 2022, the State Administration of Pharmaceutical Products urgently and conditionally approved the application of Riel Biotechnology Co., Ltd. to add COVID-19 to the treatment indications. On August 1 1 day, the approved price of azifudine tablets was 1mg per bottle of 270 yuan, with 35 tablets per bottle. It needs to be used under the guidance of a doctor. On June 8, 65438+20231October/KLOC-0, AZF tablets were officially included in the medical insurance catalogue as 1 1.58 yuan/tablet /3mg.