Gender: male
Date of birth 1970.3
Professional title professor/doctoral supervisor
Biomedical research institute, subject group
Research direction: tumor molecular biology
Research direction:
Signal transduction of tumor cells; Protein omics study of tumor: Screening of tumor-specific markers; Screening of natural anti-tumor drugs
Learning experience:
1997-2000, Ph.D. in Biomedical Engineering, School of Life Science and Technology, Huazhong University of Science and Technology.
1992- 1995, master, majoring in biochemistry, School of Biological Sciences, East China Normal University.
1988- 1992, bachelor degree, majoring in biology, biology department, Shandong Normal University.
Main work experience:
June 2007 to present: Professor, Institute of Biomedical Sciences, East China Normal University.
2005. 12-2007.5: Lecturer, University of South Florida School of Medicine.
2001.1-2005.11:postdoctoral fellow, H. Lee Moffitt Cancer Center &; research institute
February 2000 to August 2000: Research Assistant, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University.
1997.5 -2000. 12: Lecturer, School of Life Science and Technology, Huazhong University of Science and Technology.
1995.8- 1997.5: teaching assistant, School of Chemical Engineering, Tianjin University.
Teaching situation: progress in biochemistry, biotechnology, life science and advanced biochemical technology.
Main research expertise:
1. Oncology: Study on signal transduction of tumor cells, DNA damage and repair.
2. Cell molecular biology: cell proliferation, differentiation and apoptosis, aging and its molecular mechanism.
3. Biochemistry: Nucleic acid interacts with protein, protein and protein, and is modified after being translated by protein transcription machine.
4. Biotechnology: biosynthesis of plant secondary metabolites, separation and purification of natural products.
Scientific research projects:
1. Hosting scientific research projects: Hosting 2008-20 10, National Natural Science Foundation. Project approval number: 30772523
2. Participate in scientific research projects:
1) June 2007. -Up to now: Shanghai Science and Technology Commission's public service platform construction project, presided over by Liu Jiaoshou, Institute of Biomedicine, East China Normal University: establishing a cell signal network research technology platform.
2) 2001.1-June 2006: Attended the NIHRO 1CA90273: Mutant p53 Stabilizing MDM 2 hosted by Dr. Chen.
3) February, 2000-August, 2000: Biosynthesis of ginsenoside from cultured ginseng cells led by Dr. Wu Jianyong of Hong Kong Polytechnic University.
4) 1997.7 -2000. 12: National Ninth Five-Year Science and Technology Project (96-C02-03-0 1): Pilot study on taxol production by plant cell culture.
5) Project1998.12-2000.12: 863 (102- 12-0 1): Plant cell culture and production.
Scientific research achievements:
In recent five years, innovative achievements have been made in cell cycle regulation, tumor cell apoptosis and cell signal transduction. Published more than 2 papers 1 in academic journals at home and abroad, and applied for invention patent1in China. SCI included 12 articles, affecting the shadow sum by 50. This article has been cited by foreign publications for more than 200 times. Catalogue of foreign papers:
1. Wang Chuangui, Hou Xinghua, Neha Cabra, Ma, Nemoto, Torun Finkel, Douglas Crespo and Chen Jiandong. The interaction between E2F 1 and SirT 1 regulates the apoptosis response to DNA damage. Natural cell biology. 2006,8:1025-31.(sci impact factor: 22. 122)
2. The contribution of interaction between Wang Chuangui, Ivanov A, Chen L,,, Seto E, Rauscher, Chen J. MDM 2 and nuclear co-repressor Kap 1 to p53 inactivation. EMBO Daily, No.24, 2005, pp.3279-90. (SCI impact factor: 10.456)
3. Wang Chuangui, Hou X, Mohapatra S, Ma Y, Cress WD, Pleker, Chen j. e2f 1 Activation p27kip 1 Expression. A negative feedback mechanism. Journal of Biochemistry. 2005，280: 12339-43。 (SCI impact factor: 6.7)
4. chuan, Chen J. Phosphorylation and heat shock protein 90 binding medium stabilize p53 by heat shock. Journal of Biochemistry.2003,278 (3): 2066-71. (SCI impact factor: 6.7)
5. Wang Chuangui, Ma, Douglas Crespo and Wang Chuangui. Without pRb, KAP 1 contributes to the negative regulation of E2F 1. Journal of biochemistry. August 2007 17: 17704056. (In printing, SCI impact factor: 6.872)