Magnetic therapy has a history of thousands of years in China, and it is the most important application technology and research and development direction of diabetes therapeutic instrument at present. Mainly divided into single magnetic field and composite magnetic field, from single magnetic field to composite magnetic field. In the past, magnetic therapy instruments were generally single magnetic field, and some developed into compound magnetic field. Some magnetotherapeutic instruments can not only produce alternating magnetic field, but also produce pulsed magnetic field or pulsating magnetic field. The pulse frequency can be adjusted and applied selectively.
The world's leading diabetes therapeutic instrument is the first truly diabetes therapeutic instrument in China, which has won three national invention patents by using the low-frequency alternating rotating magnetic field and its unique two-way composite technology. Diabetes therapeutic instrument not only has obvious hypoglycemic effect, but also has unique therapeutic effect on various complications caused by diabetes.
According to the literature about the biological effect of magnetic field produced by diabetes therapeutic instrument at home and abroad, it mainly has the following effects on diabetes.
First, the influence on blood cells and hemorheology.
Under the action of magnetic field, leukocytes produce stress reaction, which strengthens cell metabolism and changes the ultrastructure of some cells, which may also be one of the reasons for leukopenia. Magnetic field increases the volume of red blood cells and their oxygen-carrying capacity, which is beneficial to improve blood supply and oxygen supply to tissues and promote metabolism.
Influence of magnetic field on hemorheology: Liang Luguang et al. [4] reported that a rotating magnetic field with a magnetic induction intensity of 0.09T was applied to the abdomen of rats, and a magnetic sheet with a surface magnetic induction intensity of 0.25T was applied to the abdomen of rats for 30 minutes each, *** 1 week, and then hemorheological indexes such as whole blood specific viscosity, plasma specific viscosity and hematocrit were determined. Results Under the above magnetic field, the influence of magnetic field on hemorheology of patients with diabetic cerebrovascular disease. After the constant magnetic field between poles was 2.93T, the indexes of hemorheology changed and the blood viscosity decreased, especially in patients with cerebral infarction. The author's research shows that magnetic field can improve hemorheology.
Second, the influence of magnetic field on tissue healing
Liang Yingquan et al. [9] reported that in order to observe the influence of static magnetic field on tissue healing, the histopathology and therapeutic effect of 25 cases of chronic leg ulcer were observed, and the results showed that static magnetic field could accelerate wound healing. In the magnetic therapy group, a magnetic sheet with a diameter of 50mm and a magnetic induction intensity of 0.06 ~ 0.08 t was used, and the N pole was aimed at the wound. After treatment 15 days, the small blood vessels and capillaries proliferated obviously, and the blood vessels dilated, congested and endothelial cells swelled, while the control group had similar phenomena only 35 days later. On the 35th day, the epidermis at the edge of the ulcer in the magnetic therapy group proliferated parallel to the skin surface, while the epidermis in the control group did not proliferate obviously, indicating that the static magnetic field can promote the proliferation of small blood vessels and capillaries, accelerate the growth of epidermis, and thus promote the healing of ulcer, and the time is shortened by more than one third compared with the general therapy. For example, the healing time of the ulcer edge towards the center in the magnetic therapy group was (20.60 4.21) days, while that in the control group was (36.47 6.1) days, and the difference was very significant (P < 0.0 1).
The above research shows that magnetic field can not only accelerate the healing of soft tissue injury, but also promote the healing of hard tissue fracture.
In order to study the mechanism of magnetic field promoting tissue healing and repair, the effect of magnetic field on DNA synthesis was studied. The research on the influence of alternating magnetic field on DNA synthesis shows that alternating magnetic field can promote DNA synthesis. Mice with brain injury were placed in an alternating magnetic field with magnetic induction intensity of 9.5× 10-3T-3t, and exposed to the magnetic field for 24 hours every day. The control group did not add any conditions. Three days after operation, the mice in the two groups were 65438 0,2 respectively. Three weeks later, the synthesis of tritium labeled thymine (3H-TDR) was taken as an index to study the effect of alternating magnetic field on DNA synthesis in tissue repair. The results showed that the incorporation of 3H-TDR as a marker of DNA synthesis gradually increased, which was significantly higher than that of the control group at 2 and 3 weeks after operation, suggesting that alternating magnetic field can increase the uptake of 3H-TDR in brain tissue after injury and promote the synthesis of cellular DNA, which is beneficial to brain tissue after injury.
Thirdly, the influence of magnetic field on scar tissue.
A rotating magnetic field with magnetic induction intensity of 0.08 ~ 0.09 t was applied to the artificial scar of rats for 20 minutes each time. After 4, 6, 8 and 65 438+00 days, respectively, the scar tissues of rats in the magnetic therapy group and the control group were observed by light microscope and electron microscope, and the differences in tissue structure and quantity of fibroblasts, fibroblasts and myofibroblasts were observed. However, in the electron microscope observation, it was found that there were obvious differences in the morphology and quantity of the above cells, indicating that the magnetic field could promote the broken fibroblasts to complete their repair function ahead of schedule, but promote the degeneration of myofibroblasts, reduce collagen metabolism and play a therapeutic role in scar tissue. Another author [1 1] reported that after operation, a rotating magnetic field with magnetic induction intensity of 0. 1T was applied to the incision of rabbits, each time acting for 15 minutes, once a day, * * 1 5 times, and observed. As a result, the epidermis thickened under the light microscope.
4. Effects on some enzymes and free radicals
The rotating magnetic field with magnetic induction intensity of 0.08 t was applied to the common carotid artery of rats for 20 minutes, and the effects on phospholipase A2(PLA2) and endothelin (ET) in ischemia-reperfusion rats were observed. After 30 minutes of global cerebral ischemia-reperfusion, the activity of PLA2 in rat tissues and the content of ET in brain tissues and plasma increased significantly, and the ultrastructure of cerebral cortical neurons and blood-brain barrier was obviously damaged. However, at the beginning of reperfusion, PLA2 activity in brain tissue and ET content in brain tissue and plasma decreased, and the ultrastructure damage of nerve cells and blood-brain barrier was lighter than that in model group. The experimental results show that the rotating magnetic field can inhibit the activity of phospholipase A2 and reduce the content of endothelin, which has a preventive and therapeutic effect on cerebral ischemia-reperfusion injury. The author thinks that the exact mechanism of rotating magnetic field inhibiting phospholipase A2 activity and reducing endothelin content needs further study. Liu Hongyu [17] reported that mice were placed in an alternating magnetic field with a magnetic induction of 0.5mT for 24 hours a day, and samples were taken at 3 days, 1, 2 weeks and 3 weeks after operation, respectively, to detect the activity of γ -glutamyltransferase in brain tissue. Results the activity of γ -glutamyltransferase in alternating magnetic field group increased at different time after operation and reached the peak at 3 weeks. The control group without magnetic field was14.410.3, which indicated that alternating magnetic field could improve the activity of γ -glutamyltransferase in brain tissue after injury, promote amino acid uptake and protein synthesis, and be beneficial to repair. It is considered that the above results provide an effective experimental method for further exploring the effect of magnetic field on nerve tissue and the mechanism of nerve tissue repair.
Regarding the influence of magnetic field on free radicals, domestic research results show that magnetic field has the function of scavenging free radicals. When a rotating magnetic field with magnetic induction of 183mT was applied to isolated blood for 30 minutes, the activity of superoxide dismutase (SOD) increased significantly, while the lipid peroxide decreased significantly. After a magnetic head acted on the right upper abdomen for 30 minutes, SOD, total antioxidant capacity and glutathione increased significantly, while lipid peroxide decreased significantly, indicating that magnetic field can inhibit free radicals and enhance antioxidant capacity. Regarding the scavenging effect of magnetic field on free radicals, Guo et al. [2 1] reported the effect of constant uniform magnetic field on superoxide dismutase in mice. The constant uniform magnetic field with magnetic induction intensity of 0.35T was used for 2 hours a day for 7 days, but there was no significant difference in SOD level between the experimental group and the control group, indicating that it had no effect on SOD level under the experimental conditions.
Diabetes therapeutic instrument using laser technology
Diabetes therapeutic instrument adopts nano-laser technology and is widely used in many fields. The clinical value of low-intensity laser irradiation therapy has been affirmed at home and abroad, and literature retrieval found that it is mainly used to treat diabetes, cardiovascular diseases, malignant tumors, rhinitis and other diseases. According to the research results of health medicine, low-intensity laser has a good preventive effect before and after the onset of diabetes, and has a certain effect on health and inhibiting human aging.
It combines the traditional Chinese medicine theory with the specific therapeutic function of meridian points, and develops a professional rehabilitation physiotherapy instrument for treating diabetes and improving complications through cutting-edge technologies such as intermediate frequency pulse technology, bioelectromagnetic technology, including drug iontophoresis technology.