When it comes to febuxostat, many people must be very unfamiliar, because the incidence of hyperuricemia in the population is not high, which is not as terrible as hypertension and heart disease.
febuxostat is a commonly used drug for reducing uric acid in clinical medicine, which is essentially an oxidase inhibitor. It can promote the excretion of acid receptors and uric acid in human body by promoting invertase to inhibit the transformation of urine purine.
In addition, febuxostat can directly inhibit the activity of invertase, thus inhibiting the synthesis of uric acid in human body and essentially reducing the uric acid content in human body.
febuxostat can also facilitate the dissolution of uric acid crystal salt in human body, reducing uric acid level to 4%. Generally speaking, you can see the good effect of febuxostat after taking it for two weeks. However, febuxostat is a short-acting drug, which must be treated for a long time. At present, there is no specific experiment to prove that febuxostat can play a good role in a short time.
Therefore, if you are a patient with hyperuricemia and have no other adverse symptoms, it is best to treat your body with combined medication.
For gout patients, the purpose of taking febuxostat is to effectively control uric acid in human body, so that uric acid is in a stable state, thus avoiding the recurrence of gout, reducing the recurrence of acute gouty arthritis in human body and helping to dissolve gout stones in human body.
for gout patients, the content of uric acid should be reduced to below 36u u. If you have developed tophus in your body, it is best to control the value of blood uric acid below 3u, and then consider reducing the dosage of the medicine after keeping uric acid in a stable state. After controlling your condition, you can stop taking the medicine under the advice of a doctor.
it should be noted that you should not stop eating, otherwise the blood concentration in the human body will not be stable, which will lead to the fluctuation of blood uric acid again, and finally gout will recur in the human body.
hyperuricemia is a chronic metabolic disease. Only when uric acid is at a stable level for a long time can it effectively prevent various injuries to the heart, blood vessels, kidneys, brain and limbs.
Therefore, it takes us a long time and patience to reduce the level of uric acid in human body. Even if the uric acid level drops during the intermission, don't stop taking it immediately to avoid the uric acid level rebounding immediately.
when taking febuxostat, we should pay attention to the possible side effects of febuxostat. First, it may cause damage to the liver function, causing skin adverse reactions and gastrointestinal adverse reactions.
For example, the body is covered with large and small rashes, which makes people feel nausea, vomiting and constipation. Februstat is mainly excreted through the liver. For patients with mild liver injury and patients with moderate liver injury, Februstat can play a good role in the human body, but if you are a patient with severe liver injury, try to stay away from Februstat.
second, febuxostat can also pose a threat to the kidneys. Although febuxostat is not excreted through the kidney, people with severe renal insufficiency should try to stay away from febuxostat. People with mild renal insufficiency can take febuxostat. The filtration value of febuxostat in glomerulus is 3, which is not suitable for patients with severe renal insufficiency.
If you must take febuxostat for the treatment of diseases, try to adjust the dosage with the help of a doctor, and set the initial dosage of febuxostat as 2mg, once a day.
thirdly, febuxostat may cause gout in human body. When the content of uric acid in the human body is very low, a large amount of urate will be deposited in the blood, leading to gout in the human body. At the beginning of taking febuxostat, we may see frequent gout attacks.
In this case, don't stop the treatment of febuxostat. You can also take other anti-inflammatory and antipyretic drugs, such as aspirin, to treat your gout.
fourthly, febuxostat can increase the incidence of cardiovascular and cerebrovascular diseases in human body. A scientific research institute conducted a special study, and they organized several gout patients to treat uric acid is too high with febuxostat.
The results show that febuxostat will increase the possibility of people suffering from cardiovascular and cerebrovascular diseases. The possibility of cardiovascular and cerebrovascular diseases is closely related to the dosage of febuxostat. If the dosage is 8 mg, there is a 13% possibility of cardiovascular and cerebrovascular diseases.
If the dosage exceeds 8mg, such as 12mg and 24mg, the incidence of cardiovascular and cerebrovascular diseases in human body is 52%. However, if you take 4 to 8 mg of febuxostat every day, your body will be in a safe state, and the incidence of cardiovascular and cerebrovascular diseases in your body will not be too high.
Therefore, the dosage of 4 mg to 8 mg is relatively safe. Once the dosage exceeds 8 mg, we should pay attention to the adverse reactions of the body to avoid the occurrence of cardiovascular and cerebrovascular diseases in the human body.
Fifthly, when febuxostat makes blood uric acid fluctuate violently, it can also cause the sudden attack of acute gout. At this time, we can use celecoxib and ibuprofen anti-inflammatory drugs for treatment, and we can also use colchicine to control the recurrence of gout in the human body.
Sixth, febuxostat can also cause jaundice in human body. If your face is yellow and your spirit is gradually weak, you should immediately check your kidney function.
Sometimes, gastrointestinal adverse reactions will bring more or less influence to people's lives, such as reducing people's appetite and causing people's abdominal discomfort. If the amount of transaminase is seriously higher than the normal level, stop taking the drug immediately and go to the hospital for a comprehensive examination to determine whether it is the discomfort brought by non-busetaxel.
when febuxostat is easy to bring people side effects, we should pay attention to the medication. Generally speaking, paying attention to the following four points can not only make uric acid content reach the standard quickly, but also reduce the harm caused by side effects to the human body.
First, observe your physical characteristics and identify whether you are suitable to take febuxostat to reduce uric acid. Generally speaking, some people in uric acid is too high need to take drugs to reduce uric acid for the treatment of diseases.
For patients with hyperuricemia who have gout, febuxostat can produce good effects in their bodies. During taking it, febuxostat can inhibit the activity of xanthine and prevent xanthine from producing uric acid.
febuxostat will have a good effect in their bodies, which will make the concentration of uric acid suddenly decrease in a short time, quickly prevent urate from being released into the blood, and prevent gout from happening in the human body.
For patients who have no obvious symptoms of gout, patients who have no joint pain should not take febuxostat easily, lest febuxostat drastically reduce uric acid and cause people to suffer from gout and gout.
It should be noted that patients who are being treated with purinergic drugs and patients who are being treated with thiopurine drugs should not be used with febuxostat.
second, when using febuxostat, avoid the sudden increase of drug dosage in a short time. We should gradually increase the dosage of febuxostat under the fair evaluation of doctors, so as to avoid the excessive dosage of febuxostat in human body, which will cause the drastic fluctuation of uric acid in a short time.
generally speaking, febuxostat can play a good role in reducing uric acid when used alone, and 8 mg of febuxostat can be taken every day. 8 mg of febuxostat can not only make the content of uric acid in human body reach the standard, but also promote the excretion of uric acid in human body, and will not bring great harm to renal tubules.
thirdly, when taking febuxostat, we should pay attention to whether febuxostat will bring cardiovascular and cerebrovascular diseases to ourselves. Sometimes febuxostat is suitable for some patients with high safety in their bodies, while some patients will have adverse reactions of gastrointestinal system, as well as adverse reactions of joint system and abnormal liver function.
febuxostat will bring them some threats, such as the recurrence of cardiovascular and cerebrovascular diseases and other cardiovascular and cerebrovascular diseases.
in 219, China's drug administration revised the drug instructions of febuxostat, adding a warning in the drug instructions: febuxostat will bring people cardiovascular and cerebrovascular diseases and increase the risk of death from cardiovascular and cerebrovascular diseases.
Therefore, when taking febuxostat, we should pay attention to the adverse reactions caused by febuxostat. If you have shortness of breath, dyspnea and chest pain, stop taking the medicine immediately and go to the nearest clinic for specific treatment, so as not to make the primary disease more dangerous.
fourth, we don't need to blindly pursue imported non-busetas. Generally speaking, each brand of febuxostat can play a good role in the human body, and you can choose your favorite according to your own economic conditions.
No matter Sun brand febuxostat produced by Indian companies, domestic Ulitong febuxostat, and Japanese Teijin brand febuxostat can all have good effects in human body, so don't blindly pursue the original drug.
Many people will be curious about the reason of high uric acid content. At present, there is no specific experiment and data to determine the specific reason of high uric acid, which may be related to the unhealthy diet people eat. Sometimes, eating too much high purine food, such as exogenous uric acid, will make the uric acid content of human body continue to rise.
Therefore, the high purine diet is also the main reason for the rising uric acid. Sometimes strenuous exercise will make people's uric acid suddenly rise. When the synthesis of uric acid increases, the excretion of uric acid will decrease. Anaerobic exercise will produce a lot of lactic acid, which in turn will inhibit the excretion of uric acid from the body, and will also lead to an increase in uric acid content.
For patients with gout, attention should be paid to the intake of alcohol, so as to prevent alcohol from inhibiting the decomposition of fat and sugar in the human body, so that a large number of lactic acid and ketone bodies can gather in the human body, and then the excretion of uric acid in the human body can be inhibited. Avoid excessive drinking alcohol at one time, and avoid gout attacks caused by excessive increase of blood uric acid.
(high uric acid hazard)
When taking febuxostat, we should go to the hospital to check the filtration value of glomerulus and the efficiency of glomerular reabsorption, and observe the secretion amount and degree of glomerulus, so as to avoid the influence of febuxostat on the excretion of uric acid and the normal filtration ability of glomerulus.
sometimes, a small dose of aspirin or a large dose of diuretic antihypertensive drugs can be used together with febuxostat to achieve 1+1 >: 2, effectively avoiding the sudden rise of uric acid in a short time.
(gout process)
If there are patients with high uric acid in your family, you must pay attention to your physical condition, and high uric acid will also be passed on to yourself with genes. It has been proved that 6% of hyperuricemia is related to heredity.
Through the analysis of this article, you must have understood the harm of high uric acid and how to effectively treat uric acid is too high. I hope this article can bring you some help and make you more clear and convenient in treating hyperuricemia.