Can cause gastrointestinal reactions, leukopenia, and liver damage. Daily intravenous infusion of 266 mg/m2 of this drug may cause central nervous system toxicity, manifesting as myalgia and tenderness, insomnia, and weakness. Severe myalgia lasts for 7 days after the completion of the course of treatment. It also has toxic effects on the kidneys, affecting the function of the renal convoluted tubes and causing polyuria, glycosuria, or temporary changes in bicarbonate or phosphate in the serum. There have been reports of unexpected acid-base balance and electrolyte disorders, and even deaths