Who can tell me the classification and related functions of GABA receptor in detail, focusing on the similarities and differences between type A receptor and other receptors, and what are they respons

Who can tell me the classification and related functions of GABA receptor in detail, focusing on the similarities and differences between type A receptor and other receptors, and what are they responsible for? GABA(g- aminobutyric acid) is the main inhibitory neurotransmitter in the central nervous system of vertebrates.

According to their different pharmacological characteristics, GABA receptors can be divided into three types: GABA-A, GABA-B and GABA-C receptors. GABA-A receptor/channel can be blocked by bicuculline; Baclofen can activate GABA-B receptor. However, GABA-C receptor/channel is insensitive to bicuculline and baclofen.

Both GABA-A and GABA-C receptors can form ligand-gated chloride channels, while GABA-B receptor belongs to G protein-coupled receptor family and has K+ and Ca2+ channels.

GABA-A receptor is the main inhibitory receptor in the central nervous system, and barbiturates and benzodiazepines act on GABA-A receptor, exerting its pharmacological effects such as sedation, hypnosis and anticonvulsant.