Aesculus chinensis extract is derived from Aesculus chinensis extract. ), Aesculus Chinese Bge. var。 Zhejiang aesculus or aesculus. That is, Aesculaceae in China. Warm and sweet in nature, liver and stomach meridians entered. It has the effects of soothing liver, regulating qi, regulating stomach and relieving pain, and can be used for treating qi stagnation of liver and stomach, abdominal distension, and epigastric pain.
Aescin is the main active component of Aesculus chinensis extract. The national drug standard contains six kinds of aescin preparations: sodium aescinate for injection, sodium aescinate tablets, sodium aescinate liniment, compound sodium aescinate gel and compound sodium aescinate gel.
Pharmacological Effects of Aescin
Anti-inflammatory and anti-exudation effects of 1
Aescin has obvious inhibitory effect on granuloma and can significantly improve inflammatory exudation. It has obvious inhibitory effect on pulmonary inflammation caused by adrenaline and endotoxin, and can be used to prevent and treat acute pulmonary inflammatory exudation of acute pneumonia. The product is added with transdermal agent. The normal absorption efficiency of skin is generally less than 7%, and more than 93% of various effective ingredients are wasted, which will cost consumers a lot of money. Seven-leaf soothing spray has a very efficient transdermal agent, which improves the use efficiency and has a more obvious effect.
2 Anti-brain edema effect
Aescin has a significant therapeutic effect on brain edema after cerebral hemorrhage, and can reduce the water content in various brain regions.
3 Anti-tumor effect
Aescin-1a can be transformed by crude enzymes of intestinal bacteria and Lactobacillus brevis to produce deacetylated aescin ⅰ, which has anti-tumor activity, inhibits the growth of sarcoma, liver cancer and lung cancer cells, and obviously inhibits the proliferation of nasopharyngeal carcinoma cells (KB).
4 increase venous tension
Sodium aescinate can obviously increase the contraction tension of saphenous vein strip, increase its reactivity to norepinephrine, obviously strengthen the tension of femoral vein and accelerate the increase of venous pressure; Significantly increased femoral vein flow and lymphatic reflux in dogs. It has certain therapeutic effect on chronic venous insufficiency.
Protective effect of 5 on gastrointestinal tract
Malt extract can obviously promote intestinal peristalsis and has a good protective effect on gastric mucosal injury caused by anhydrous alcohol. Malt extract has the effect of resisting gastric ulcer caused by aspirin.
Protective effect of 6 on ischemic injury
Sodium aescinate has obvious protective effect on focal cerebral ischemia-reperfusion injury, and can significantly improve the volume of cerebral infarction after cerebral ischemia-reperfusion, reduce brain edema and improve neurological symptoms. Matrix metalloproteinase -9 (MMP9) and laminin (LN) may be involved in the formation and development of cerebral vasogenic brain edema. Sodium aescinate can protect the brain from ischemia-reperfusion by decreasing the expression of mMP9 and increasing the expression of LN in the early stage of ischemia-reperfusion. Sodium aescinate has protective effect on intestinal mucosa after intestinal ischemia-reperfusion
7 others
Malt extract has obvious inhibitory effect on gastric acid secretion. Aescin has a strong antibacterial effect, and the antibacterial effect intensity increases with the increase of drug concentration.
Application of Aescin
Aescin can be used for treating cerebral hemorrhage, brain edema, limb swelling, diarrhea, radiation proctitis, Meniere's disease, senile bronchial asthma, peripheral facial neuritis, burn, lumbar disc herniation, epidemic encephalitis B, Guillain-Barre syndrome, diabetic foot and other diseases.
References:
1. Modern research progress of Ma Lishan Lingyun, Lee Sang-il and other traditional Chinese medicines. Asia-Pacific Traditional Medicine Vol.8 No.8 20 12