Treatment of bone metastasis of lung cancer;
①
Systemic anti-tumor therapy (chemotherapy, biological targeted therapy, etc.). ): Systemic chemotherapy can control the development of bone metastasis and relieve pain while treating primary lung lesions, so it can not only relieve pain, but also kill cancer cells and control their growth. In particular, high-dose cisplatin combined with chemotherapy is more effective. Molecular targeted therapy drugs such as Irbil, Iressa and Trocquer have been widely used in clinic.
② Surgical treatment: local metastasis resection, bone cement fixation and repair, etc.
③
Radiotherapy (including radioisotope internal irradiation): Radiotherapy can be divided into 60 Co irradiation, deep X-ray machine and linear accelerator. For solitary bone metastases, after the lung lesions are controlled and stabilized by chemotherapy, large dose and short course of radiotherapy can be given to relieve pain, kill cancer cells and control the development of the lesions. About 50% patients can completely relieve pain after radiotherapy, and about 75% patients can obviously relieve pain. Patients with multiple bone metastases are not suitable for radiotherapy, and radionuclide therapy can be used at this time. At present, strontium 89 is the most widely used. Radionuclides can reduce bone destruction and dissolution caused by bone metastasis, eliminate or alleviate severe pain caused by bone metastasis, and inhibit the development of bone metastasis. However, because it can also cause bone marrow suppression reaction, it is not suitable to be combined with chemotherapy in principle, and the changes of white blood cells should be observed regularly.
④ Analgesic treatment: Narcotic analgesics such as morphine hydrochloride, morphine sulfate, dihydroetorphine tablets and Durogesic plaster can obviously relieve the pain caused by bone metastasis and improve the quality of life of patients.
⑤
Bisphosphonate treatment: such as bone phosphate (disodium chloromethyl diphosphate), Bonin, Akdag (disodium pamidronate), zoledronic acid and other phosphate drugs, but also calcium chloride. These drugs can resist the osteolytic effect of metastatic bone tumors and reduce the risk of pathological fractures.