Second, the curative effect is remarkable and it is not easy to relapse;
Third, it is convenient to use and has high compliance;
Fourth, it does not contain hormones and is safe to use;
5. Leading technology and domestic patents.
Instructions for use of EMBOCK cream-anti-human interleukin -8 mouse monoclonal antibody cream
[Drug Name]
Generic name: anti-human interleukin -8 mouse monoclonal antibody cream
Product name: Enbok Cream
[Main components]
Anti-human interleukin -8 monoclonal antibody, 45μg/g cream.
[sex]
This product is a white odorless cream (O/W cream).
[Pharmacology and Toxicology]
Interleukin -8 has chemotactic effect on neutrophils. According to literature reports, the concentration of interleukin -8 in the skin of psoriasis lesions is higher than the normal level, which may be one of the factors for the early formation of psoriasis lesions. The results of animal experiments suggest that the mechanism of this product may be to reduce the aggregation of neutrophils by neutralizing interleukin -8 in local tissues, thus reducing the inflammatory reaction of skin. Monoclonal antibodies can effectively neutralize excessive interleukin -8 in psoriasis lesions, thus preventing neutrophils from infiltrating into the skin, inhibiting the abnormal proliferation of epidermal keratinocytes, eliminating inflammation and achieving the purpose of treating psoriasis.
[Pharmacokinetics]
After this product is applied to psoriasis skin, the anti-IL -8 monoclonal antibody in the cream slowly penetrates into the skin lesions, and combines with IL -8 in the skin lesions to form an immune complex, which is directly digested by phagocytes in skin tissues. Therefore, the amount of free monoclonal antibodies entering the blood through skin tissue is extremely small and cannot be detected. No anti-mouse immunoglobulin (HAMA) reaction was found in the patient's serum after treatment with this product. According to the literature, the serum half-life of mouse-derived monoclonal antibody injected into human body is 65438 0.9 days, but there is no report that mouse-derived monoclonal antibody is detected in serum for external use.
[indications]
This product is a mouse-derived monoclonal antibody against human interleukin -8, which can be used to treat psoriasis vulgaris.
[Usage and dosage]
After cleaning the diseased skin, remove dandruff as much as possible, and apply this product to the diseased area twice a day, with a total dose of 10g/ day, 40-70g per week, and 6 weeks as a course of treatment, or as directed by the doctor.
[Adverse reaction]
Skin irritation reactions such as itching, burning sensation and erythema can be seen after using this product, which generally does not affect the treatment.
[contraindications]
Those who are allergic to this product are prohibited, and local or systemic infection is prohibited.
[Notes]
1, this level of mouse-derived anti-human interleukin -8 monoclonal antibody may also produce allergic reaction under the condition of local external use, so it should be closely observed.
2. Pregnant women and lactating women should use this product with caution if the kidney and heart function are abnormal.
3. The maximum application area of this product is more than 20% of the body surface area.