(1) can enhance the weight of immune organs, relieve bone marrow inhibition, enhance the function of immune organs and promote the formation of immune cells.
⑵ Increase the number of T lymphocytes, macrophages and neutrophils, and enhance the cellular immune function that directly kills pathogens and tumor cells.
⑶ It can increase the quantity of immunoglobulin produced by B lymphocytes, and enhance humoral immunity of neutralizing toxin by increasing antibody content.
⑷ Protect the human immune system. Decreased immune function → increased free radicals in the body → aggravated immune system damage. Polygonatum odoratum tea pigment has a strong antioxidant function, which can prevent free radicals from damaging the immune system and protect the body.
5] Anti-interference, stable immune regulation. Clinical practice has proved that Polygonatum odoratum tea pigment can improve immune function, and it is extremely stable and accurate. Even if it interferes with immune function (such as arteriosclerosis), it can still stabilize the immune regulation mechanism, which is very important for middle-aged and elderly people with low immunity and resistance reduction factors to maintain disease resistance.
2. Polygonatum odoratum tea pigment can regulate immune dysfunction.
⑴ Polygonatum odoratum tea pigment can inhibit immune hyperfunction (allergic reaction). With the pollution of human living environment, allergic diseases are gradually increasing and becoming younger, which is related to immune abnormality. Allergic reactions can be divided into four types:
Type I: IgE (reactive element)-causes sensitized body to release allergic active substances such as histamine, slow reactant (SRS-A) and kinin, which leads to contraction of bronchial smooth muscle, increased secretion of glands and dilation of capillaries. In severe cases, systemic allergic reaction (anaphylactic shock) occurs, and in mild cases, local allergic reaction (asthma, urticaria) occurs.
Type ⅱ: IgG- glomerulonephritis.
Type ⅲ: IgM- endocarditis, vasculitis, insulin reaction, etc. Cardiovascular and cerebrovascular diseases and diabetes are related to this type.
Type ⅳ: infectious diseases such as tuberculosis and leprosy caused by T cell immune response.
Experiments show that low concentration of tea pigment can reduce IgE level, reduce the production of histamine and SRS-A, activate cAMP enzyme to increase the concentration of cyclic adenosine monophosphate, inhibit the release of histamine and stop allergic reaction.
⑵ Polygonatum odoratum tea pigment is used to treat tumors caused by immunosuppression.
The process of tumor cell formation is divided into:
In the initial stage (normal cell canceration)-promotion stage (cancer formation)-proliferation stage (rapid proliferation of cancer cells), Polygonatum odoratum tea pigment has inhibitory effect on tumors in all three stages.
A, bamboo tea pigment can remove cancer cells in the initial stage of cell differentiation at the start-up stage to prevent abnormal cell reproduction. Polygonatum odoratum tea pigment prevents the continuation of the start-up period by inducing cancer cells to commit suicide, which is a breakthrough in tumor immunotherapy.
B, Polygonatum odoratum tea pigment has triple killing effect on cancer cells in the promotion period. On the one hand, tumor cells are directly killed by T cell subsets: CD4, CD8, CD3 and NK cells; On the other hand, tumor necrosis factor secreted by lymphocytes, macrophages and neutrophils can directly attack and destroy tumor cells; In addition, tumor cells are dissolved by immunoglobulin secreted by B cells.
C. Polygonatum odoratum tea pigment can prevent the proliferation of cancer cells. In the proliferation stage, the tumor not only spreads to the surrounding tissues like gnawing, but also transfers to other tissues through lymph and blood, especially when the blood flow is slow, it is easier to spread. Polygonatum odoratum tea pigment can prevent tumor spread and control disease development by improving hemorheology, promoting microcirculation and delaying cancer cell metastasis.
D, for patients with advanced cancer, in the process of comprehensive radiotherapy and chemotherapy, Polygonatum odoratum tea pigment can alleviate bone marrow suppression, increase blood cells, control infection, improve anemia and bleeding, improve immunity and achieve the purpose of reducing side effects.
E. Tea pigment has obvious inhibitory effect on tumor markers (alpha fetoprotein, carcinoembryonic antigen, sialic acid). Due to the proliferation of abnormal cells, the hemorheology of tumor patients is in a state of high viscosity, high coagulation and low flow, which leads to microcirculation disturbance. Polygonatum odoratum tea pigment can reduce blood viscosity and improve microcirculation.
F. The clinical effects of tea pigment on various tumors are as follows:
① Precancerous lesions of gastric cancer: moderate and severe intestinal metaplasia improved obviously, with a total effective rate of 93.75%;
② Gastric adenocarcinoma: inhibition of gastric adenocarcinoma cell line MKN-45, with an inhibition rate of more than 50%;
③ Acute promyelocytic leukemia (HL-60): induced apoptosis of HL-60 cells, the effective rate was 42.91%;
④ Radiosensitization of malignant tumor: The effective rate of tea pigment combined with radiotherapy was 68.2%;
⑤ Serum markers of malignant tumor: Tea pigment can significantly reduce serum sialic acid as a marker of malignant tumor, and the reduction rates are: breast cancer 13.7%, lung cancer 18.2%, liver cancer 210.4% and gastrointestinal cancer 22.3% respectively.
3. In the treatment of immune deficiency, Polygonatum odoratum tea pigment has a strong inhibitory effect on HIV reverse transcriptase, HIV DNA polymerase and RNA polymerase. Become a new hope for the treatment of AIDS. At the beginning of this chapter, tea pigment in a broad sense has been mentioned, which refers to the pigment components in tea trees and the pigment components that form the color of tea soup after brewing into tea. However, the tea pigment highlighted in this book is one of the narrow tea pigments. So, what is this narrow sense of tea pigment? How is it formed?
As early as 1959, British biologist Robert studied the oxidation products of catechins in tea, and finally completed the theoretical study of the products and determined the molecular structure, named "tea pigment".
In fact, the so-called tea pigment, that is, the water-soluble, small-molecule, phenolic oxidized polymer generated by oxidative polymerization of tea polyphenols extracted from tea leaves, is a kind of medicinal substance with extremely high biological activity, and its main components are theaflavins, thearubigins and theabrownins. Thearubigins is the main component of tea pigment, and its content accounts for more than 85% of the total tea pigment.
So what are the functions of theaflavins, thearubigins and theabrownins? According to medical experts:
The toxin has the functions of anticoagulation, promoting fibrinolysis, reducing blood viscosity, preventing platelet adhesion and aggregation, accelerating blood metabolism and improving oxygen carrying capacity of blood cells.
Thearubigins can increase serum high density lipoprotein, reduce blood lipid and serum low density lipoprotein, inhibit the activities of reverse transcriptase of retrovirus and DNA and RNA polymerase of various cells, and dissolve blood vessel deposits. Tea brown pigment has the functions of increasing the toughness and elasticity of blood vessels, repairing the intima of blood vessels, and preventing and treating hypertension and diabetes.
More importantly, the unique multiple pharmacological effects of tea pigment can completely resist the seven risk factors of cardiovascular and cerebrovascular diseases without any toxic or side effects, and it will become a new generation of green and ideal fundamental therapeutic drugs for cardiovascular and cerebrovascular diseases and a major breakthrough in the field of cardiovascular and cerebrovascular diseases drugs.
This discovery shocked the whole international medical, biological and pharmaceutical fields, and its great influence went deeper into many related fields. The discovery of tea pigment has undoubtedly given all patients with cardiovascular and cerebrovascular diseases a beam of dawn and brought infinite hope. However, the content of natural tea pigment in tea is very small, and the previous extraction technology is very complicated and relatively backward. Only 0.6 ~ 1.6 kg can be extracted per ton of tea, and the yield is extremely small.
Because of the high biological activity and poor structural stability of tea pigment, its biochemical characteristics are easily changed by time and temperature, resulting in weakened function and efficacy, and the requirements for storage conditions are extremely strict, so tea pigment is very rare and extremely expensive. These restrictive factors greatly limit the popularization and application of tea pigment, so tea pigment is praised as "green gold in medicine" by the world medical community.
The research and application of tea pigment in China has always been in the leading position in the world.
With the development of biotechnology in China, the extraction technology of tea pigment has been continuously improved, and its yield, quality, biological activity and stability have been greatly improved. The continuous and fruitful scientific research results of tea pigment enable this once "noble" to serve the public as a basic medicine for the benefit of ordinary people.
As the latest generation of pure natural medicinal ingredients, tea pigment has a wide range of therapeutic and health care functions. Clinical verification shows that taking 4800 times is not only effective, but also has no toxic and side effects. These unique characteristics have aroused widespread concern in the world medical field and become the most advanced "international competition topic" of medical science and technology in developed countries.
As early as 1993, China built the world's first modern production line to extract "green gold-tea pigment", and became the first country in the world to industrialize "tea pigment" and obtained an invention patent.
This is a milestone achievement in the modernization of tea medicine!