Zhang Xingqun,1born in June 1963, Ph.D., associate professor of microbiology and molecular biology at Donghua University. Deputy Director, Department of Biological Engineering, Institute of Biological Science and Technology. Head of microbiology and fermentation engineering course.
Chinese name: Zhang Xingqun
Nationality: China.
Ethnic group: Han nationality
Date of birth: 1963 65438+ 10 month.
Occupation: teacher
Masterpiece: Modern Enzymology (Second Edition)
Title: Associate Professor of Microbiology and Molecular Biology, Donghua University
brief introduction
Master tutor. Director of Marine Biochemistry and Molecular Biology Branch of China Society of Biochemistry and Molecular Biology, Director of Industrial Biochemistry and Molecular Biology Branch of China Society of Biochemistry and Molecular Biology, Member of Marine Bioengineering Committee of Marine Medicine Branch of Chinese Medical Association, and Member of Marine Microbiology and Molecular Biology Committee of Marine Medicine Branch of Chinese Medical Association. Member of marine medicine professional Committee of Shanghai pharmaceutical society. Part-time researcher and deputy director of academic Committee of Henan Bioengineering Technology Research Center. Special evaluation expert in marine science and technology field of Ministry of Science and Technology.
research direction
He has been engaged in scientific research in the fields of molecular microbiology and genetic engineering for more than 20 years in the front line of teaching and scientific research in colleges and universities. The research content involves the upstream biotechnology of gene cloning and engineering strain construction, the midstream fermentation technology of engineering analysis of microbial fermentation process and the downstream technology of separation, purification and detection of expression products. After coming to Donghua University in 2004, I mainly studied marine biotechnology and textile biotechnology. At present, my research is as follows:
1. Cloning, functional analysis and heterologous expression of functional gene cluster of marine microorganisms, screening of drug lead compounds of marine microorganisms.
2. Molecular modification and directed evolution of industrial enzymes based on molecular biology technology.
3. Structural modification of marine biological collagen and research on nano biomedical functional materials.
Major achievements
1, completed two projects of the National Natural Science Foundation and six provincial and ministerial funds of the Ministry of Education.
2. Published 40 research papers.
3, through the provincial and ministerial scientific research achievements appraisal 4.
4. Publish four academic works.
5. Apply for 4 patents.
6. In 2008, the innovative project for college students directed by the Ministry of Education won the top ten in China, and it was also the only selected project in biology.
project
1, National High-tech Research and Development Plan (863) in the field of marine technology.
2. General Project of National Natural Science Foundation.
4. Key Laboratory Cultivation Fund Project of Ministry of Education of Eco-textile.
5, "Textile Biomedical Materials Science and Technology Innovation Introduction Base"No. B07024 "Open theme.
6. Songjiang District Economic Commission Industry-University-Research Project.
Thesis works
1.isolationfnewpolyketidesynthasegenefragmentsandpartialgenecluster from east China seaandfunctionanalysis of newacyltransfrase， appliedbiochemistry and biotechnology， 149( 1)，67~~78，2008
2. Characteristics of a new isolate of stenotrophomonas with high keratinase activity and purification of the enzyme, Journal of Microbial Biotechnology, 36, 18 1~ 188, 2009.
3. Isolation and partial identification of a new polyketide synthase gene cluster, China Journal of Antibiotics, 33(3), 134 ~ 139, 2008.
4. Recombinant expression and substrate binding analysis of a novel acyltransferase AT-EF08095 1, China Journal of Antibiotics, 33(3), 140 ~ 144, 2008.
5.6 Multiplex PCR Detection of Food Pathogens, Journal of Clinical Laboratory, 2005, Volume 23, No.4..
6. Preparation of Recombinant Human OCIF Active Domain Polypeptide Fusion Protein by High Density Fermentation, Microbiological Bulletin, 3 1(6), 53 ~ 56, 2004.
7. Expression of recombinant human OCIF domain D 1 ~ D6 gene in Pichia pastoris, Journal of Molecular Science, 20(4),1~18, 2004.
8. Fusion expression of active domain fragment of human osteoclast formation inhibitor in Escherichia coli, China Journal of Biological Products, 18(2), 85-88, 2005.
9. Fusion expression of mature peptide gene of human osteoclast formation inhibitor in Escherichia coli, academic journal of second military medical university, 25( 10), 1086 ~ 1089, 2004.
10. Escherichia coli TB 1 optimal conditions for high-density culture /PMAL- hotchhoffm, Journal of East China University of Science and Technology (Natural Science Edition), 3 1( 1), 72 ~ 75, 2005.
1 1. Application of bacterial two-hybrid system in extracellular interaction. Academic journal of second military medical university, 2003; 24
12. Tissue Culture and Plant Regeneration of Gentiana macrophylla, Acta Botanica Northwest, 2005, Vol.25, No.6.
13. Investigation Report on Lichens in Ganling, Cultural Relics Protection and Archaeological Science, Vol.4, 2002,No. 1
14. Quantitative analysis of natural medicine components (China Medical Science and Technology Press)
15. Modern Enzymology (2nd Edition) (East China University of Science and Technology Press)
teaching
1. Hosted two excellent courses and discipline construction projects of Donghua University.
2. Instruct the Ministry of Education and Shanghai University Students' Innovative Experimental Project.
Undergraduate Teaching Courses: Microbiology, Principles of Biotechnology
4. Postgraduate teaching courses: biochemical reaction engineering, enzymology and enzyme engineering
5. Doctoral teaching course: modern bioengineering
Academic exchange
At present, it cooperates with protein Purification Laboratory of NEB Company of the United States, Jiao Research Group of Department of Biochemical and Molecular Biology of the Second Military Medical University, and five domestic bioengineering companies.
Please click Donghua University, School of Biochemistry, Faculty and Associate Professor to find contact information.