According to the theory of selective peripheral nerve regeneration and nerve regeneration amplification, a small gap sleeve suture method is proposed to replace the traditional epineurium suture method, and experiments in mammals and primates have been carried out step by step, all of which have achieved reliable repair results, confirming the feasibility of replacing the traditional epineurium suture method with small gap sleeve suture method. At the same time, the bio-cannula with independent intellectual property rights has been developed, so that the small gap sleeve suture technology is expected to become a new method to repair peripheral nerve injury.
The biological basis and extension limit of peripheral nerve are systematically studied, which provides a reliable theoretical basis for nerve extension technology to repair nerve defects. The hypothesis that nerve regeneration is regulated by many factors is put forward, and the effect of Radix Hedysari on promoting peripheral nerve regeneration is confirmed by animal experiments.
According to the phenomenon of nerve regeneration amplification and the theory of small gap socket suture technology, the feasibility of repairing thick nerve with small nerve was verified by animal experiments.
A total of 25 papers were published in the above-mentioned related research, 7 of which were included by SCI in SCI journals such as Constructive Microsurgery, Eurpean Neurology, Artificial Cells Blood Substance and Biotechnology. He has successively won 3 invention patents, 2 Beijing Science and Technology Progress Awards and the Chinese Medical Association 1 Science and Technology Progress Award. In 2006, the National Fund for Distinguished Young Scholars funded related research.
Clinical and Basic Research on Bone and Joint Injury
Lead the discipline of trauma orthopedics in many well-known hospitals in the United Nations, and conduct standardized retrospective research on periarticular fractures. This research has been included in the Tenth Five-Year Plan and the special training program of major science and technology projects of Beijing Science and Technology Commission, and won the "Eleventh Five-Year National Science and Technology Support Plan". The research goal of this project is to complete the standardized treatment guidelines for periarticular fractures. The research results have been published in more than 20 domestic journals and magazines, and the citation rate has reached 173 times by the end of 2006. Published 2 related monographs, translated 1.
Starting from the phenomenon that the fracture healing speed of patients with central nervous system injury is obviously accelerated, combined with the obvious increase of serum calcitonin gene-related peptide (CGRP) concentration in such patients, the correlation between calcitonin gene-related peptide (CGRP) and fracture healing was systematically studied, in an attempt to find related substances that can effectively promote fracture healing. The research results were published in magazines such as Artificial Cells. Related research on blood substance and biotechnology has been included in the National "973" Project and the Capital Development Fund Project.
By observing the pedicle of vertebral arch with reconstructed CT, a large number of anatomical data of pedicle were summarized, and the relationship between the diameter of pedicle screw and pedicle isthmus was clarified. The pedicle internal fixation was changed from empirical operation to scientific operation based on preoperative CT measurement, and the concept of "pedicle isthmus" was first put forward in the world, and related research was published in the authoritative magazine Spine of orthopedics.