The second generation sequencing is high-throughput sequencing, which uses microbeads or high-density chips to synthesize sequencing at the same time, representing the amounts of 454, solexa, solid and Qualcomm, and can obtain several grams of data at a time. Compared with the third generation, it still needs amplification method to amplify the signal, and then detect it after amplification. The core idea of the second generation sequencing technology is synthetic sequencing, that is, the sequence of DNA is determined by capturing the newly synthesized terminal tag. The existing technology platforms mainly include Roche /454 FLX, Illumina/Solexa genome analyzer and solid-phase system of applied biological system. The second generation sequencing technology greatly reduces the sequencing cost, and at the same time greatly improves the sequencing speed and maintains high accuracy. It used to take three years to complete the sequencing of a human genome, but it only takes 1 week to use the second generation sequencing technology.
For more information about the second generation sequencing, please consult Hyplos. The patented reagent independently developed by Hyplos can accurately capture DNA fragments of different cancers, and the success rate of the patented reagent is over 99%, and the capture depth is highly uniform. Its medical laboratory has the world's top gene sequencing platform and a perfect international standard quality system, and has passed the authoritative certification of CAP (American Association of Pathologists) /EMQN (European Molecular Gene Diagnostic Quality Alliance)/Clinical Laboratory Center of China Ministry of Health, covering the whole process of tumor management, genetic disease screening, major infectious diseases (including COVID-19 nucleic acid) and other fields. It has been used by more than 500 3A hospitals, hundreds of scientific research institutes, medical institutions, insurance companies and Internet platforms.
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