Patent of Polylactic Acid Modified Chitosan

Using biological manufacturing technology to obtain artificial organs is a promising method to replace allogeneic and xenotransplantation and electromechanical artificial organ implantation. Biomedical information is the physiological and geometric basis of biological manufacturing, while biomaterials are the material basis of biological manufacturing. This paper summarizes and compares the formation and application of common biomaterials from the perspective of biomaterial formation methodology, and points out that biomanufacturing technology is the most promising method to obtain scaffolds and tissue precursors with complex spatial structure and biological functions.

PLA hydroxyapatite PGA collagen chitosan gelatin scaffold 3d printer 3D rapid prototyping machine melting at low temperature and high temperature.

Biomaterial 3d printers, rapid prototyping machines for 3D printing of biomaterials, and rapid prototyping machines for 3D scaffolds of tissue engineering are traditionally formed by powder stacking technology, high-temperature melting technology and low-temperature molding technology.

The advantage of powder stacking technology is that the sample volume is relatively large.

The technology of high-temperature melting molding is that customers can use suitable raw materials, and the highest temperature can reach more than 200 degrees.

Low temperature molding technology can keep the activity of biomaterials from losing, and the lowest temperature can reach 3 degrees.

At present, the commonly used biological implant materials or tissue engineering scaffold materials are:

Natural medical degradable materials: natural, safe and abundant.

The natural materials commonly used to construct tissue engineering scaffolds mainly include collagen, chitosan, gelatin and so on.

Collagen degradation and absorption in tissue healing

Chitosan is the product of deacetylation of chitin, and it is the only basic amino polysaccharide in known natural polysaccharides. It is non-toxic, non-irritating, biocompatible and biodegradable.

Non-antigenic gelatin with high protein content

The common methods are: gelatin and natural polymer materials, gelatin and synthetic polymer materials, gelatin and bioceramic materials.

cellulose

Silk fibroin Silk fibroin can be made into various forms (including porous structure).

Synthetic polymer material

Polylactic acid (PLA) is suitable as extracellular matrix material.

Modification of polyglycolic acid fiber is a research hotspot.

Polylactide (PGLA) has the advantages of polyester material.

There are two kinds of composite materials: one is a composite material of natural polymer and synthetic polymer, such as collagen-PGA; The other is the combination of organic materials and inorganic materials, such as hydroxyapatite-polylactic acid, hydroxyapatite-chitin and so on.