1. Antibacterial effect: Borneol can inhibit or kill common clinical bacteria such as Staphylococcus aureus, beta-hemolytic Streptococcus, viridans Streptococcus, etc. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration ( MBC) are 1.0%~1.5% and 1.5%~2.0% respectively. The main components borneol and isoborneol have the same effects as borneol, but there is neither antagonism nor synergy between the two components. Borneol also has antibacterial effects on five common fungi such as rubrum rubrum. The principle of its action is related to the fact that borneol easily penetrates the cell wall, causing damage to the cell membrane, destroying it and changing its permeability.
2. Anti-inflammatory effect: Both borneol and isoborneol, the main components of borneol, can inhibit the swelling of rat paws caused by egg white. The principle may be related to antagonizing PGE and inhibiting the release of inflammatory mediators, but For the swelling of mouse ear pinna caused by croton oil, the inhibitory effects of the two components are not exactly the same, and the effect of borneol is not obvious.
3. Analgesic effect: After using borneol directly on the laser burn wound, the pain threshold of the animal model was 2.78 times and 6.24 times higher than that of the Jingwanhong group (positive control) and the normal saline group (negative control) respectively. The use of compound preparations containing borneol to treat various clinical pains has also been reported from time to time.
4. Others: Borneol can promote the division and growth of glial cells (Schwann cells), and its effect is similar to that of musk. The optimal concentration is 0.04%, and 72 hours of culture is the most vigorous period of growth. . Borneol can also cause miscarriage in mid- and late-pregnancy mice, with pregnancy termination rates of 100% and 91% respectively, but has no obvious effect on early pregnancy