In the early 1930s, Moshe (Frederick E. Moshe) was still a medical student, studying under Professor Michael F. Gay of Wisconsin. Professor Gayer was then the head of the Department of Zoology and an excellent geneticist. Together, they studied the different inflammatory responses of tumor and normal tissues in mice to various stimuli. During the experiment, they happened to find that not only tumor tissues and normal tissues would be necrotic after injection of zinc chloride solution, but also the structure and even cell morphology of these necrotic tissues were well preserved under the microscope. 1944, Mohs applied for a patent with the fee of 1 to the Wisconsin Alumni Research Fund. In the following ten years, as a pioneer and advocate of tissue fixation technology, Mohs was also the only practitioner of this new technology. From 65438 to 0956, Mohs published the first monograph of Chemical Surgery. Because of his long-term unremitting exploration and practice, as well as his rigorous and realistic academic spirit, the good effect of "chemical surgery" shocked the skin science community, and the technology was finally recognized worldwide.
1986 Due to the dominant application of fresh tissue technology, the American College of Chemical Surgery was officially renamed as American College of Mohs Microsurgery and Dermatology (ACMMSCO). Since then, "chemical surgery" has become "Mohs microsurgery".
To sum up, Mohs microsurgery is not a fine operation under microscope, but a combination of surgical resection, chemical tissue-specific section or special frozen section detection methods (horizontal frozen section and staining) and plastic repair technology. It requires practitioners not only to have a solid foundation in dermatology, especially histopathology, but also to be proficient in plastic surgery and other fields.