Abstract: [Purpose] To find the best agent to prevent and treat viral diseases and reduce the losses caused by viral diseases. [Method] A comparative test was conducted on the effectiveness of several common antiviral agents on the market in preventing and treating tobacco virus diseases. [Results] The survey results show that the average control effects of Virus Special, Virus Bike, Pure Land Ling, Pyrimicin, Dongwang Killer, Kangzhuangsu, and Jinyebao are 45.3, 40.3, 39.4, 29.0, 26.7, and 25.3 respectively. and 25.1. [Conclusion] Antiviral agents such as Kangzhuangsu, Pyrimidin and Dongwang Virusicide have good prevention and control effects on tobacco viral diseases; Viruses, Virus Bike, Jingtuling and Jinyebao are effective in preventing and treating tobacco viral diseases. It is less effective, but it also has a certain control effect on tobacco virus diseases.