Name: Polyethylene glycol (PEG) series; common chemical names: polyethylene glycol PEG, ethylene glycol polyoxyethylene ether
Chemical structure: HO(CH2CH2O)nH , polymerized from ethylene oxide.
Products can be divided into several series such as pharmaceutical grade, cosmetic grade, food grade and industrial grade.
The properties of pharmaceutical grade, cosmetic grade and food grade are as follows:
The Dow Chemical Company first commercialized the production of polyethylene glycol in 1940 and is now recognized as the world leader in the industry. who. In 1992, Dow Chemical Company's commitment to quality was recognized and it became the first U.S. polyethylene glycol manufacturer to obtain ISO9002 certification for its production quality system. Its CARBOWAX SENTRY brand polyethylene glycol passed the U.S. FDA certification and complied with United States Pharmacopeia (USP), National Formulary (NF), Food Chemical Codex (FCC) standards are widely used in the production of food, pharmaceutical, feed, personal care products, chemicals and other industries, and are well-known and trustworthy brands in the industry.
Main uses:
1. PEG-400 is most suitable for making soft capsules. Since PEG400 is liquid, it has broad compatibility with various solvents and is a good solvent and solubilizer. It is widely used in liquid preparations, such as oral liquids, eye drops, etc. When vegetable oil is not the carrier of the co-active ingredient, PEG is the material of choice. This is mainly because PEG is stable and does not deteriorate easily. Injections containing PEG are very safe and stable when heated to 150 degrees Celsius. In addition, it can also be mixed with high molecular weight (PEG) to form a mixture with good solubility and good compatibility with drugs.
2. PEG-1450 and 3350 are most suitable for making ointments , suppositories, creams. Due to its high water solubility and wide melting point range, PEG1450 and 3350 can be used alone or mixed to create a storage time field and a melting point change range that meets the requirements of drugs and physical effects. Suppositories using PEG bases are less irritating than those using traditional oil bases.
3. PEG-4000, 6000, and 8000 are used in tablets, capsules, film coatings, dropping pills, suppositories, etc.
Due to the plasticity of PEG and its ability to improve the drug release of tablets during the tableting process, high molecular weight PEG (PEG4000, PEG6000, PEG8000) is very useful as a binder for making tablets. Useful. PEG can make the surface of tablets shiny and smooth, while not easily damaged. In addition, a small amount of high molecular weight PEG (PEG4000, PEG6000, PEG8000) can prevent the adhesion between sugar-coated tablets and medicine bottles.