Side effects of sofebuvir
Side effects of taking Sophie Bouvet
It varies from person to person, and personal physique is different. Some are not obvious, basically rash, dizziness, nausea and so on.
Adverse reactions of sofebuvir
Rash is mostly dizziness and nausea, because personal constitution is different.
Recommend a comprehensive treatment plan
Simple HCV infection or HCV/HIV- 1 infection, continuous treatment; Gene 1 or type 4 sofebuvir+ peginterferon α+ribavirin, 12 weeks;
Gene type 2 sofebuvir+ Ribavirin, 12 weeks;
Genotype 3 sofebuvir+ Ribavirin for 24 weeks;
1 Patients with chronic hepatitis C who can't use interferon can consider using sofebuvir combined with ribavirin for 24 weeks.
As one of the four major liver diseases in China, hepatitis C has a large number of patients, but the treatment effect is not ideal. The listing of sofebuvir tablets in China is undoubtedly the gospel of patients with hepatitis C. At present, we are most concerned about the domestic price of Sofibuvir. If it is beyond the affordability of most patients, it is difficult and expensive to see a doctor.
Sofebuvir 2065 438+03 was very expensive as soon as it was listed in the United States. The wholesale price of 28 tablets/bottle of Sovaldi in the United States will be $28,000, that is, $65,438+0,000 per tablet. Most patients need treatment for 65,438+02 weeks, and the total cost will reach $84,000.
Its price of $84,000/course of treatment ($65,438+$0.000/tablet) is also controversial. The US House of Representatives, patient rights organizations and other organizations strongly urged Sovaldi to reduce the price, while Gilead insisted on not reducing the price, saying that the drug would save taxpayers a lot of money in the long run. After several years of listing in the United States, the price of the drug was greatly discounted compared with the initial stage of listing through commercial insurance negotiations and the subsequent listing of the second and third generation products.
At present, the domestic price has been determined, and a course of treatment of sofebuvir is less than 60 thousand yuan. Last year165438+1October 27th, Gilead announced the price of sofebuvir in China. The final price is 19660 yuan/bottle, and the sales specification is 28 sofebuvir tablets/bottle. According to every three months as a course of treatment, the price of a course of treatment is 58980 yuan.
Effective method for treat hepatitis C
One of the best treatments for hepatitis C: single-drug interferon -A in the early 1990s, the treatment for hepatitis C was 3mu, subcutaneous injection or intramuscular injection, three times a week or every other day 1 time, and the course of treatment was 12~24 weeks. Clinical research shows that about 40 ~ 70% patients with hepatitis C are effective after this dose and course of treatment. Subsequent studies have found that prolonging the course of treatment and increasing the dose can improve the efficacy of interferon. However, when the dose increases too much, the therapeutic effect of hepatitis C does not increase, but the adverse reactions increase.
The best treatment for hepatitis C: Long-acting interferon treatment Because the half-life of long-acting interferon-a is only 6 hours, its half-life is mainly determined by the metabolic process of the body. The adverse reactions of long-acting interferon are similar to those of ordinary interferon, and there is no obvious increase. For patients with chronic hepatitis C, the clearance of hepatitis C may take a long time, and the treatment of interferon also takes a long time. The emergence of long-acting interferon, in addition to better therapeutic effect, is injected once a week, with good compliance and easy acceptance by patients.
The best way to treat hepatitis C is to treat interferon with compound interferon A, which has different biological characteristics. Cifn is not a natural interferon, but a recombinant compound interferon. June 1997 was approved by fda for the treatment of hepatitis C and imported by the Ministry of Health in the same year.
The best way to treat hepatitis C: interferon combined with ribavirin. Although interferon has a certain effect on the treatment of chronic hepatitis C, the effect is not ideal, especially in some cases with poor predictable effect before treatment. Judging from the data in recent years, the short-term and long-term efficacy of interferon combined with ribavirin in the treatment of chronic hepatitis C, whether biochemical reaction or viral reaction, is significantly higher than that of interferon alone.
The best way to treat hepatitis C is to combine traditional Chinese and western medicine. Traditional Chinese medicine has a long history of treating hepatitis C. Treating hepatitis C through traditional Chinese medicine has few side effects, is safe and nontoxic, and has quick curative effect. In recent years, there are many examples and methods of treating hepatitis C with traditional Chinese medicine. Combined with western medicine therapy, it can greatly alleviate the pain of patients with hepatitis C.
Etiology of hepatitis C
Hepatitis C virus infection is the root cause of the disease. Under the influence of external factors, such as drinking, fatigue and long-term use of hepatotoxic drugs, it can promote the development of diseases. The pathological changes of hepatitis C are very similar to those of hepatitis B, mainly manifested as hepatocyte necrosis and lymphocyte infiltration. Chronic hepatitis can appear fibrous tissue hyperplasia in portal area, and in severe cases, it can form false lobules, which is called cirrhosis.
The pathogenesis of HCV infection mainly includes immune mediation and HCV direct injury, and viral factors include virus genotype, replication ability, immunogenicity of virus polypeptide and so on. Host factors include innate immune response, humoral immune response and cellular immune response. Factors such as drinking alcohol and using immunosuppressants can also affect the progress of HCV infection.
Transmission routes of hepatitis C: kissing, hugging, sneezing, coughing, food, drinking water, using tableware and cups, no skin damage and other contact without blood contact generally do not spread hepatitis C. Hepatitis C is mainly transmitted through the following routes:
1. Blood transmission
(1) blood products transmitted through blood transfusion have a window period for anti -HCV, the quality of anti -HCV detection reagents is unstable, and a small number of infected people do not produce anti -HCV, so HCV positive people cannot be completely screened out, and a large number of blood transfusions and hemodialysis may still be infected with HCV.
(2) Transmission through damaged skin and mucosa is the main mode of transmission at present. In some areas, HCV transmission caused by intravenous drugs accounts for 60% ~ 90%. The use of non-disposable syringes and needles, dental instruments without strict disinfection, endoscopy, invasive operation and acupuncture are also important ways of transdermal transmission. Some traditional medical methods that may lead to skin damage and blood exposure are also related to the spread of hepatitis C virus. * * * The use of razors, toothbrushes, tattoos and pierced earrings are also potential modes of transmission of hepatitis C virus through menstruation.
2. Sexual transmission.
3. Mother to child transmission
The risk of HCV transmission from anti -HCV positive mothers to newborns is 2%, and if the mother is HCVRNA positive during delivery, the risk of HCV transmission can be as high as 4% ~ 7%. When HIV infection occurs, the risk of transmission increases to 20%. The high load of HCV virus may increase the risk of transmission.
4. Other channels
In 15% ~ 30% sporadic hepatitis C, the transmission route is unknown.