Research results of Kangminyuan anti-allergic probiotics on endogenous causes of eczema in children and its influence on the recovery of eczema in children
Endogenous, Exogenous and Skin Barrier Function of Eczema in Children and Four Causes of Staphylococcus aureus Infection;
1. Exogenous inducing factors of eczema: food allergy: the main food allergen of children allergic to eczema under three years old is eggs >; Milk >; Soybean > wheat >; Peanuts.
2. Endogenous inducing factors of eczema: intestinal mucosal barrier dysfunction: food allergy first occurs in the intestine, because the onset site of eczema in children is in the skin, so it is difficult to connect with intestinal function, but intestinal mucosal barrier function is the first site to induce food allergy in infants, and because this cause has not attracted the attention of medical institutions and parents, the treatment of eczema in children is mostly focused on the treatment of rash, because the pathogenic factors of eczema in children cannot be fully grasped and adjusted, therefore,
3. Causes of skin mucosal damage in eczema: skin mucosal barrier damage (HDM_ protease): keratinocytes secrete more cytokines. The human skin barrier is divided into four epidermal parts:
The first layer is microbial barrier (also called bacterial barrier). When people's skin is observed under a microscope, they are all bacteria. Therefore, it is not recommended that children with eczema excessively clean their skin. Many modern new lifestyles are destroying the microbial barrier of human body.
The second layer is the physical barrier
The third layer is a chemical barrier
The fourth layer is the immune barrier.
4. Staphylococcus aureus infection: this is basically ignored in the treatment of infant eczema at present, and it is also the main reason for the sustainable development of infant eczema in the middle and late stages. It is also inseparable from the skin mucosal injury of eczema, because the long-term itch-scratch-itch-scratch of eczema children's skin forms a vicious circle, which is the main reason why Staphylococcus aureus infection stimulates the skin keratinocytes to secrete cytokines. Therefore, the baby's eczema will have moss-like thickening and blackening in the later stage.
Effect of eczema on the quality of infant;
Because skin eczema has long plagued children's growth and development, there is also a stubborn rash, which can appear in any part of the child's body. Eczema of head and face and intractable eczema of limbs have become the most typical rash types of eczema in school-age children aged 2-6 years. The biggest disease feature of eczema is itching, which can be called itching in medicine. Eczema in children seriously affects children's sleep and upcoming campus life. With the growth of children, the long-term trouble of eczema leads to the pain and depression of children and the whole family, and also leads to the loneliness of children.
Proportion of eczema in children of all ages:
(<6 months) Early infantile eczema: Eczema occurred about 30 days after birth, with a clinical incidence rate of 53%, mainly due to milk protein allergy;
(6- 12 months) Mid-term infant eczema: The clinical incidence rate is 23%, and food allergy is still the main cause, but there may be many allergens. This stage is the stage when babies begin to add complementary food, and it is also a very allergic period;
(> 12 months) Late stage of eczema in children: the clinical incidence rate is 25%, and it is easy to develop into atopic dermatitis, and the course of disease is easy to continue into adolescence.
The new progress in the basic treatment of eczema in children (anti-allergic probiotics+skin moisturizing emollient+skin antibacterial) is the basic treatment to reduce the use of skin hormones in eczema in children.
1. Early diagnosis, avoid contact with allergens.
2. Intestinal immunity of anti-allergic probiotics in children eczema: In view of the pathogenic factors of children eczema: the increase of IgE in allergic constitution-skin damage and infection-skin barrier dysfunction, which is closely related to the occurrence and development of eczema, Kang Minyuan's anti-allergic probiotics experts summarized three necessary conditions for the treatment of eczema:
1. Supplementing Kangminyuan anti-allergic probiotics (not less than 3 months) can reduce serum IgE allergic antibodies, build baby's intestinal barrier function and adjust allergic constitution; Kangminyuan probiotic formula food for special medical use: a new concept of treating eczema atopic dermatitis: eczema is treated with microbial Kangminyuan antiallergic probiotics, and intestinal flora imbalance is the main feature of eczema children. Because anti-allergic probiotics can increase the diversity of intestinal flora, regulate the activation of Th cytokines, inhibit TH2-type response, enhance TH 1 type immune response, up-regulate immune cells, and accelerate the repair of skin and mucosal barrier function.
Second, it is very necessary for anti-inflammatory treatment: external use of Baiduobang ointment to fight the infection of damaged skin;
If you take less baths, eczema will get worse when it gets wet. Moreover, eczema babies are born with imperfect skin barrier function and skin sebum layer synthesis disorder. You should take less baths and use more skin emollients to protect the skin.
Third, a large number of skin moisturizing boxes are used to care for the skin: it can resist dryness and restore the barrier function of the skin. The emollient containing medicinal urea is better, and 10% urea cream is beneficial to enhance the barrier function of patients. Moisturizing emollients can save about 50% skin hormones when treating eczema. You should use emollients to protect your skin at least twice a day.
There is an "immune tolerance" mechanism in the intestinal immune system, which will inhibit the immune system from secreting immunoglobulin E(IgE) or G(IgG) to cause allergic reactions to food ingredients. And allergic people, it is precisely because of the "immune tolerance" mechanism problems, so when eating a particular food, the intestinal immune system will secrete too much immunoglobulin E(IgE) to attack food ingredients, so they have allergies.
Allergic children lack beneficial bacteria in their intestines.
There are many kinds of allergens, such as dust mites, bacteria, pollen, protein, milk, soybeans, wheat, mold, meat and so on. Many medical studies have pointed out that allergic problems caused by "excessive secretion of IgE due to immune tolerance" are closely related to good bacteria and bad bacteria in the intestine. Studies have shown that there are fewer beneficial bacteria such as lactic acid bacteria in the intestines of allergic children. Although there are tens of thousands of lactic acid bacteria strains in nature, only a few strains have antiallergic properties. This kind of bacteria that have special regulatory effects on "immune tolerance and IgE secretion" include Lactobacillus salivarius, Lactobacillus Grignard, Lactobacillus yoelii, Lactobacillus lactobacillus paracasei and Lactobacillus Roy, which are called Kangminyuan antiallergic probiotics. The effect of Lactobacillus salivarius is to reduce serum IgE antibody, promote interferon secretion and improve Th 1 immune response. The function of Lactobacillus Grignard is to reduce serum IgG, which is helpful to reduce the secretion of cytokine IL-5 related to allergic reaction, and can effectively improve the human immune system. Kangminyuan's anti-allergic probiotics have the ability to assist in regulating allergic constitution.