2. Different characteristics: pertuzumab can be used in combination with trastuzumab, other anti-HER2 treatments and docetaxel, and it is expected to be used for metastatic breast cancer users who have not received anti-HER2 treatment or chemotherapy. Tratuzumab can also stimulate users' autoimmune cells to destroy cancer cells. Tratuzumab is a humanized monoclonal antibody derived from recombinant DNA.
3. Different antibodies: the antibody of trastuzumab belongs to IgGl type, which contains human framework region and complementary determinant region of mouse anti-p 185 HER2 antibody, and can bind to HER-2. Pertuzumab blocks the heterodimerization of HER2 with other HER receptors by binding HER2, thus slowing down the growth of tumor.
Extended data:
Precautions:
Left ventricular dysfunction: pertuzumab will lead to subclinical and clinical heart failure, which is characterized by decreased pertuzumab and congestive heart failure. Cardiac function should be monitored before and during each medication. If left ventricular function with clinical symptoms declines, medication should be stopped.
There is serious fetal toxicity. Using pertuzumab during pregnancy will harm the fetus, lead to birth defects and even death. Female patients should be reminded to take effective contraceptive measures.
Left ventricular dysfunction: monitor LVEF and stop taking drugs if necessary.
Infusion reaction: monitoring signs and symptoms. If there is a serious infusion reaction, the infusion should be slowed down or interrupted, and appropriate medical treatment should be given.
Allergy/Allergy: Monitor signs and symptoms. If there is a serious infusion reaction, the infusion should be stopped immediately and appropriate medical treatment should be given.
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