Mild protectants (such as 10% boric acid ointment and zinc oxide ointment) can be used as glucocorticoid preparations in acute phase. Drugs with strong effects, such as keratin promoters and immunosuppressants, can be used in both stable and regression periods, but they should start from low concentrations. (1) Anthracene: a powerful reducing agent, which can cause irritating dermatitis if used excessively. The conventional therapy is to start with anthracycline ointment, gradually increase the concentration of ointment within a few weeks, and continue to smear until the plaque completely disappears. (2) Preparation of tar: 2%- 10% coal tar, pine oil, black soybean oil and bran ointment are commonly used. (3) Glucocorticoid: It can be made into cream, ointment, solution, coating or packaging. However, the side effects of glucocorticoid are obvious, especially when it is used in large doses for a long time, which should be paid attention to and avoided. (4) Immunomodulators: tacrolimus ointment, pimecrolimus cream, etc. (5) Tretinoin: topical application of 0.05%-0. 1% tazarotene gel and 0.025%-0. 1% tretinoin cream for 4-6 weeks, which can be combined with super glucocorticoid or ultraviolet treatment. (6) Carbatotriol: Its ointment preparation has good curative effect for 4 weeks.
Systemic medication
(1) Glucocorticoid: It is not used for psoriasis vulgaris, but only for erythrodermic psoriasis, arthritis and generalized impetigo psoriasis, and should be used with caution when other therapies fail. Prednisone 40-60mg daily, orally or intravenously. (2) Immunosuppressants:
Methotrexate (MTX): 65,438+00-25mg/week, taken orally.
Cyclosporine: the initial dose is 2.5 mg/(kg d), which can be increased by 5 mg/(kg d) when it is ineffective.
Retinoic acid: Avia ester is commonly used. The dose is1mg/(kg d), and the maximum dose is no more than 75 mg/d; May be teratogenic.
Antibiotics: Antibiotics can be used for secondary infections. Both penicillin and cephalosporin are available.
biological agent
Keshanting (Scotuzumab injection)
Tuozi (Yiqi Zhumonoclonal antibody injection)
Cedano (gusechizumab injection)
Xiumeile (adalimumab Injection)