Levoamlodipine Maleate Tablets (Xuanning) of CSPC Ouyi Pharmaceutical Co., Ltd. obtained a splitting technology patent certificate in 2005, which removes the dextrorotary body of amlodipine.
The calcium antagonist activity of the L-body is 1,000 times that of the D-body
The L-body can avoid side effects such as acroedema, headache, and dizziness caused by amlodipine
Chiral drugs are racemates of half left-handed and half left-handed. It is like a double-edged sword. Half of it can treat diseases, and the other half may cause diseases.
Clinical trials have proven that a single enantiomer can not only eliminate or reduce the adverse reactions of the original racemic drug, but also reduce the dosage and improve the efficacy
J.E. Arrowsmith et al. The pharmacological effects of the levorotary body were further studied, and the results showed that the effectiveness of the levorotary body is 1,000 times that of the dextrorotary body, and the same dose of the levorotatory body is twice as effective as the racemic body.
Research by the American company Sepracor shows that levamlodipine can avoid side effects such as acroedema, headache, and dizziness caused by racemic amlodipine.