At present, the price of Pfizer's original drug is 53,000 yuan per box. If you take it for a long time, it is beyond the affordability of ordinary families. Even with china charity federation's drug donation policy, patients need to pay 200,000 yuan at their own expense to apply for drug donation. At the same time, patients need to consider whether to apply for drug donation without serious side effects. Once they develop drug resistance, the donated drugs will be unusable and need to be replaced or used in combination with other targeted drugs to continue treatment. So many patients ask me what is the difference between the original Pfizer in the United States and Pfizer in India, and the imitation version of crizotinib in India and Bangladesh. First of all, crizotinib produced by Pfizer in the United States or Pfizer in India has passed the original research of FDA and CFDA and is protected by patents. Only Pfizer has a much lower price in India. Bangladeshi versions (such as Bikang) and Indian versions (such as Kabuning and Lucius) are generic drugs. Although the generic drugs authorized by China are called "fake drugs" in China, it does not mean that such generic drugs are invalid. The generic drug crizotinib produced by regular manufacturers has been confirmed by many patients in terms of curative effect, but we must pay attention to distinguish between true and false. The printed version of CBN-Kzotinib can be given priority, because its raw material supplier is the same as the original drug, and the medicine box has anti-counterfeiting code, so it can be verified in official website without worrying about buying fake drugs.