What was the first infectious disease in human history?

It's smallpox, which was originally a relatively harmless pox virus on livestock. After evolution and adaptation, smallpox has become a powerful infectious disease. Smallpox is almost as old as human history.

In the early stage of infection in history, people will have high fever, headache and other diseases. After a few days, a typical smallpox rash will appear, which is obviously distributed on the face, arms and legs. After a few days, the skin lesions will start to fester until the second week. In the next three to four weeks, scabies gradually develop and then slowly peel off.

3000 years ago, people suffered from smallpox, an acute infectious disease, which was recorded in ancient China, India and Egypt. Scientists have verified from mummies that in BC 1000, Pharaoh Ramses, who ruled Egypt, had smallpox scars on his head.

Extended data:

Historical data show that smallpox killed at least 654.38 billion people, and another 200 million people were blind or left with lifelong scars. Those scars are caused by smallpox virus on the rich sebaceous glands on the face, and there is a sad nickname called pockmarked face.

It is said that the once powerful Roman Empire was unable to contain smallpox, so that its national prestige was shrinking.

References:

Baidu encyclopedia-smallpox virus