Development history of biotechnology

discovery of penicillin in 1928a. Fleming

large-scale industrial production of penicillin in p>1943

1944 .t. Avery and others proved that DNA is genetic material by experiments

1953 J.D. Watson and F.H.C.Crick discovered the double helix structure of DNA

1961-1966 deciphered the genetic code < A ⅱ restriction endonuclease

1972 DNA recombination technology was established

1975 g.j.f. Kohler and C.Milstein established hybridoma technology

1976 DNA sequencing technology was born

1978 produced genetically engineered insulin for the first time

198 The US Supreme Court ruled that genetically engineered products could be patented

198. The first transgenic animal (mouse) was listed on NASDAQ in p>1981. Birth

Livestock vaccine produced by DNA recombination technology was listed in Europe for the first time

In p>1983, artificial chromosomes were successfully synthesized for the first time

In p>1985, gene fingerprinting technology appeared in court for the first time as evidence

In 1986, the first genetically modified crop was approved for field test

In 1986, the first human vaccine (hepatitis B vaccine) was recombined with DNA. Successful development

1988 PCR technology came out

1989 transgenic insect-resistant cotton was approved for field test

199 the first somatic cell gene therapy test was approved in the United States

199 the human genome project was officially launched

199 the first transgenic animal (salmon) was approved for breeding

1993 BIOengineering Industry Organization (Bio). Established

Transgenic fresh-keeping tomatoes were listed in the United States in p>1994

Dolly, the first cloned sheep, was cultivated in Britain in p>1997

The human embryonic stem cell line was established in p>1998

The working frame of human genome in p>2 was completed

The gene map of rice, an important food crop in p>21, was completed in China

The sequencing of human genome in p>23 was completed.