Is it useful to eat coenzyme q 10 and DHEA during excretion promotion? After eating DHEA, the basal follicles decreased?

The number of follicles is fixed at birth, and no new follicles are produced afterwards. From 12 years old to adolescent 13 years old, the follicles in the follicular pool are regulated by the hormone of hypothalamus-pituitary-ovary axis, and a batch of primordial follicles are awakened and enter the process of growth and maturity, which lasts for more than 30 years. Once these primordial follicles are awakened, they embark on the "no return" of growth. Hu (hanyu pinyin)

The whole development process takes about 200 days until ovulation, and it goes through the stages of primordial follicle, preantral follicle, sinus follicle, growing follicle, mature follicle and ovulation.

In the ovary, a batch of follicles enter the new "follicular production line" every month. Under normal circumstances, the follicle development hormone and feedback provided by the human body can only supply one dominant follicle in the follicular pool, and only one follicle can be obtained from the follicular pool in a menstrual cycle, and two follicles are occasionally seen, waiting to be combined with sperm. (Is it useful to eat coenzyme q 10 and DHEA during excretion promotion? After eating DHEA, the basal follicles decreased? )

What about the other follicles? Because there is not enough "material", it is locked, shrunk and disappeared.

If there are no high-quality eggs discharged or more eggs are needed, ovulation induction is needed to help sisters get pregnant.

During this period, some people will eat DHEA and coenzyme q 10. Does it really work?

DHEA, known as dehydroepiandrosterone in Chinese, is a kind of weak androgen, which is mainly secreted by adrenal gland and is the precursor hormone of steroid hormone synthesis in female follicles. For women, the main function is to improve ovarian function, help pregnancy, improve autoimmune and protect cardiovascular system. At present, it is commonly used in clinic to treat premature ovarian failure, infertility and irregular menstruation.

However, DHEA is a supplement to androgen, so androgen is too high to eat polycystic. DHEA can also produce side effects, such as acne, hair loss and palpitation. Because DHEA can stimulate the secretion of growth hormone, and too much growth hormone will lead to the formation of cancer cells in the human body, too much DHEA in the body may also cause cancer. DHEA will also increase the risk of prostate cancer, breast cancer and uterine cancer, and even make these hormone-sensitive cancer cells more active and worse. Therefore, it is not recommended that patients who feel premature ovarian failure blindly take DHEA without a clear diagnosis.

DHEAAMH, a derivative of 2065 438+00 DHEA, was newly developed in Europe and America, and France presented a more convincing research report. It has been proved that DHEAAMH not only supplements DHEA and prevents its genetic variation, but also plays a significant role in improving the quality of ovaries, follicles and eggs.

Different from pure DHEA, DHEAAMH has gathered more than 30 patented energy factors, which can intensively and urgently raise eggs, nest and other energy factors for fertility maintenance. Dehydroepiandrosterone is regarded as an energy source to assist pregnancy in Europe. Britain, Germany and many other European countries have done a lot of research on DHEAAMH. At present, DHEA AMH in China is mostly imported from abroad. In recent years, the application of dehydroepiandrosterone in patients with ovarian dysfunction has been recognized by many countries. According to the survey, about13 fertility centers around the world began to add DHEAAMH to patients with ovarian dysfunction.

Compound pregnancy repair factor DHEAAMH- premature ovarian failure improvement system

Premature ovarian failure improvement system-providing backup guarantee for oocyte quality

Significance analysis of DHEA AMH: DHEA balances the hormone level of the pre-pregnancy mother, and AMH increases the egg reserve function.

In this survey, the infertility rate of premature ovarian failure and abnormal ovarian function is 0. 1%, but the clinical manifestations of premature ovarian failure are high FSH level and amenorrhea. The occurrence of premature ovarian failure seriously affects women's psychological state and fertility, causes endocrine disorders, and greatly reduces the probability of pregnancy.

When a woman is born, there are about 2 million follicles in the ovary, but only 400-500 follicles eventually mature, and most of them will die with age. The phenomenon is the decline of ovarian function, the disappearance of ovulation function and the decline of fertility function. Normal women have 65,438+02% eggs in their ovaries at the age of 30, but only 3% eggs remain at the age of 40. In addition to the function of the egg itself will decline with age, when women approach menopause, the menstrual cycle will become more disordered, and the endometrium will become thinner, which is even less suitable for fertilized eggs to implant. At the same time, vaginal discharge is reduced and vagina is dry, which is not conducive to the entry of sperm.

Ovarian stem cells stop proliferation and differentiation after aging, so that ovarian follicular pool can not be replenished, leading to ovarian function decline and ovulation stop. It can be seen that the aging of ovarian stem cells may be the fundamental reason for the decline of ovarian function. Many studies have shown that the proliferation and differentiation of ovarian stem cells are regulated by immune factors (immune cells and immune factors). In this experiment, after DHEAAMH supplementation, compared with the control group, the expression of immune factor protein in high, medium and low dose groups increased significantly, the function of macrophages increased, and the number of follicles increased, which verified that immune function regulated reproductive function, indicating that DHEAAMH could enhance female reproductive function.

The use of dehydroepiandrosterone has a beneficial effect on the quality of oocytes and embryos. The observation that DHEAAMH is related to improving the cumulative embryo score shows that this treatment can improve the quality of embryos and eggs. The strong trend of increasing embryo ploidy and pregnancy rate further supports this suggestion.

The dose of dehydroepiandrosterone is about 65438 03 g/day to about 26 g/day for women. DHEAAMH therapy can be applied to premenopausal women with weakened ovarian function, which has a statistically significant effect on the cumulative embryo score after about 2 months, but its effect can be continuously increased to about 4 months, or about 16 weeks, and can be used for more than 4 months.

The cumulative embryo score of women before using DHEAAMH may be about 34. After continuous use of DHEAAMH for at least about four months, the cumulative embryo score may be at least about 90, and the cumulative embryo score may increase by at least about 64. There was significant difference in cumulative embryo score before and after treatment with dehydroepiandrosterone (P

Ovarian reserve reduces the number of female aneuploid embryos and embryo transfer. Pretreatment with DHEAAMH for at least about 65438 0 months, preferably at least about 4 months, can increase the number of oocytes and embryos, the quality of eggs and embryos, the cumulative pregnancy rate, IVF rate and pregnancy time in women. (Is it useful to eat coenzyme q 10 and DHEA during excretion promotion? After eating DHEA, the basal follicles decreased? )

Coenzyme Q 10 can not only provide power for the heart, but also have excellent antioxidant and free radical scavenging functions, which can prevent lipid peroxidation and atherosclerosis in blood vessel wall.

Ovulation promotion is based on the type of ovulation or anovulation of patients and the purpose of medical intervention, hoping to obtain multiple mature oocytes. Ovarian stimulation can be divided into ovulation induction (OI) and controlled ovarian stimulation (COS).

-1-OI refers to stimulating the ovaries of anovulatory women to form a normal ovulation cycle (imitating the selection and ovulation of a physiologically superior follicle and restoring normal physiological functions). ?

Suitable for the following people:

Polycystic Ovary Syndrome (PCOS) and Hypothalamic Ovulation Disorder are the common infertility patients with fertility requirements but persistent anovulation and rare ovulation.

Luteal insufficiency;

Infertility and recurrent abortion caused by ovulation disorder (follicular dysplasia);

Others such as intrauterine insemination (IUI), unexplained infertility, mild endometriosis (EMs) and so on.

-2-COS aims to induce the development of multiple dominant follicles, that is, multiple oocytes mature to increase the probability of pregnancy.

It is suitable for patients who need IVF-ET and its derivatives.

Today we will talk about in vitro ovulation induction.

Ovulation promotion in vitro is to make these follicles mature due to lack of substances through external supplementary substances. In this way, sisters who originally had only one egg a month, or even failed to ovulate due to illness, have more possibilities of pregnancy.

Because ovulation induction is the reuse of follicles that may be wasted, there is no "will ovulation induction lead to follicle reduction?" Such a question.

The number of eggs in the follicular pool is the basis for obtaining the number of eggs in the final egg collection. A clever woman can't cook without rice, and the eggs obtained by ovulation induction are of good quality and large quantity, which can provide great help for embryo culture and transplantation. Then the following three key issues have also become the "heart disease" of many test-tube mothers. Let's have a look.

1. Before ovulation induction, I said that there may be 10 multiple follicles. How can I get 3 or 4 follicles?

At the beginning of a week (usually the second day of menstruation), the doctor will judge the number of basal follicles, basic hormones, AMH and other comprehensive evaluation of ovarian reserve function through B-ultrasound, and then start to promote ovulation. In the process of ovulation induction, drugs will induce multiple follicles to develop at the same time, and the date of taking eggs will be determined when most follicles mature.

Because these follicles vary in size, some follicles are over-mature, and eggs have begun to die from presbyopia. Some eggs are immature and difficult to suck out. Sometimes sinus follicles may have no eggs, that is, empty follicles. Therefore, there will be a discrepancy between the judgment at that time and the actual number of eggs taken.

2. My friend took more than 20 eggs, but I only took two or three, and I only took one at a time! Why is this?

Many test-tube sisters are worried about the small number of eggs. After all, there is no embryo without eggs, and the possibility of success is relatively small.

1. Age factor: With the increase of age, the number of eggs in follicular pool will decrease, and the number of eggs obtained by ovulation induction will also decrease.

2, premature ovarian failure: a small number of young people, ovarian aging in advance, the number of eggs in the follicular pool decreased in advance, and the number of eggs obtained by ovulation and egg retrieval will also decrease. This is why sisters who are also promoting ovulation, but do test tubes because of the decline of ovarian reserve function, get fewer eggs than sisters who do test tubes simply because of fallopian tube problems! Because everyone has a different base.

3. Low ovarian response: the follicles in the follicular pool have poor response to exogenous follicle-stimulating hormone, which makes it difficult to grow and mature, and will also lead to fewer eggs.

4. Empty follicles: There is no problem with the number of basal follicles in the follicular pool, but the eggs in the follicles are missing. For example, eggs, only egg whites, no yolk. Embryologists can't find eggs after taking them, which is one of the reasons why they take fewer eggs. It should be pointed out that the incidence of empty follicle syndrome is very low in actual clinical work.

5. Other factors: If the egg retrieval technology is not mature, it may lead to the loss of eggs, but this situation is unlikely to happen, because every egg retrieval doctor has undergone strict training for more than ten years, and the egg retrieval technology needs long-term observation and supervision from superior doctors before it can be carried out alone.

3. I took 13 eggs to develop 4 embryos, and the transplantation failed twice. What should I do?

Implantation is a life-and-death battle for embryos, and the quality of embryos directly affects the success of implantation. If the eggs to be eliminated according to the laws of nature are promoted by medical means, there will be no distinction between good and bad, especially in patients with decreased ovarian reserve function.

These eggs are not all excellent, even in the morula stage, doctors can't predict their future development potential. Medicine can only increase everyone's probability of success, but it cannot guarantee the possibility of 100%.

A high-quality egg will have a greater success rate. How to improve the quality of eggs? There are two main aspects: medical care and life conditioning:

-1- medical treatment

Mainly under the guidance of experienced doctors, choose the appropriate ovulation induction scheme and pretreatment scheme to obtain high-quality follicles as much as possible and prepare for obtaining high-quality embryos. Every doctor has his own unique experience and understanding in the choice of drainage promotion scheme. What we need to do well is "cooperation".

In addition, under the guidance of a doctor, related vitamins and trace elements (including vitamin D and vitamin C, etc.) can be supplemented. ), antioxidant treatment, TCM conditioning and other methods to improve the overall physical fitness. You can also use health care products to help yourself get more and better eggs.

More and more clinical data show that DHEAAMH has good clinical effects in promoting follicular growth, increasing the pregnancy rate of implanted embryos and reducing aneuploidy (chromosome abnormality), especially in helping infertile patients in IVF to obtain more and better eggs and effectively reducing the incidence of abortion. The abortion rate of IVF using DHEAAMH is 50% to 80% lower than that of national IVF.

The elderly and patients with low ovarian response can be supplemented 2 months before ovulation induction therapy or test tube cycle, and can be taken continuously.

-2- life adjustment

This is also a very important part, including reducing staying up late, getting enough sleep, living a regular life, eating a nutritious and healthy diet, strengthening outdoor sports and other healthy lifestyles.

For people with poor ovarian function, many experienced doctors are not in a hurry to conduct ovulation-ovulation cycle immediately. In order to ultimately improve the success rate, patients are often required to adjust their health first, and then choose the most appropriate time for core medical care.

The adjustment of lifestyle seems simple, and some people even doubt its function. However, in the actual clinic, we have observed that many patients with premature ovarian failure have long-term life problems such as staying up late, long-term mental stress, excessive dieting and weight loss. Know that the body will not lie, and be truly responsible for your body.

I hope everyone can promote ovulation and get pregnant smoothly. (Is it useful to eat coenzyme q 10 and DHEA during excretion promotion? After eating DHEA, the basal follicles decreased? )