From 1948, Comrade Shen Rongxian's research on the prevention and treatment of veterinary infectious diseases in China has gone through two stages, namely, from cultivating and domesticating attenuated vaccines with different animals to cultivating and domesticating attenuated vaccines with cell cultures. Shen Rongxian and others insisted on the theory that pathogenic microorganisms developed from gradual quantitative change to qualitative change in the body, strongly advocated the use of live vaccines, and successively cultivated the above vaccines such as rinderpest, sheep pox and classical swine fever. The development and successful application of these vaccines have promoted the progress of preventive veterinary medicine and immunology research in China. At that time and later, the vaccines successfully developed by veterinarians basically adopted this technical route. In the 1960s, especially after returning from studying in Romania, he improved the vaccine development from the original animal level to the cellular level, and advocated using cell culture instead of animal culture to domesticate attenuated virus, which solved the unresolved immune problem of horse-borne poverty for the first time in the world, shocked the veterinary and medical circles, and inspired people's confidence and courage in developing AIDS vaccine, which was of milestone significance for the prevention and control of lentivirus.
In 200 1 year, in the selection of "Great Achievements of Engineering Science and Technology in China in the 20th Century" jointly organized by China Academy of Engineering and China Association for Science and Technology, on the basis of comprehensive selection, the selection committee selected "the greatest achievements of engineering science and technology in China in the 20th century", and selected four important vaccines against livestock and poultry diseases, including three: 1) goat attenuated rinderpest and sheep attenuated rinderpest. In particular, he presided over the attenuated vaccine of horse transmission, which successfully "broke through the theory that lentivirus can not be immunized academically and made a pioneering contribution". China has become the only country in the world that has successfully controlled the epidemic situation of horse-borne poverty, and has maintained an international leading position in the research level of live vaccine and immunology of horse-borne poverty.
At the end of 2002, Heilongjiang Science and Technology Awards Conference was held in Harbin. Academician Shen Rongxian became the first winner of the "highest science and technology award" in Heilongjiang history and was awarded 500,000 yuan.
At the beginning of 1998, major overseas media published such a news: "China experts started with very similar equine infectious diseases, which made a breakthrough in AIDS vaccine research." Shen Lao touched the eyes of the world. He formed an indissoluble bond with cattle, horses, sheep, pigs and chickens, and together with his companions, he successfully developed a rinderpest vaccine, which eliminated rinderpest in the land of China. 1948 After the liberation of Northeast China, Shen Rongxian volunteered to work in Harbin Northeast Institute of Agricultural Animal Epidemic Prevention (predecessor of Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences). Since then, Shen Rongxian has forged an indissoluble bond with cattle, horses, sheep, pigs and chickens.
As soon as Shen Rongxian arrived at the epidemic prevention station, he joined the research group of rinderpest vaccine. At that time, rinderpest was rampant in rural areas of Northeast China, and a large number of cattle died one after another. Armed with several syringes, a homemade mortar distributor and a simple microscope, Shen Rongxian and his companions declared war on rinderpest. Vaccines were successfully developed one after another, and by 1953, rinderpest swept across Northeast China and North China was finally eliminated. In March of the same year, Shen Rongxian was dispatched by the Ministry of Agriculture and boarded the Qinghai-Tibet Plateau with a newly developed vaccine to declare war on yak rinderpest. By 1956, the rinderpest of Mongolian cattle, Korean cattle and yak was completely subdued. At this point, rinderpest was eliminated in China. He and his companions successfully developed a vaccine against equine infectious anemia, which saved the country 6.5 billion yuan in economic losses in ten years. Equine infectious anemia is a severe infectious disease with high mortality, and it has always been the most serious infectious disease that puzzles the horse industry in the world. Some foreign scholars predict that its lentivirus disease cannot be immunized.
Shen Rong explained that it was difficult. Together with his companions, relying on collective wisdom and thousands of practices, he took the lead in developing an attenuated vaccine for equine infectious anemia donkey leukocytes in the world. This is a monument in the history of lentivirus vaccine research. At this point, the theory that lentiviral diseases cannot be immunized has been broken.
So far, this vaccine is still the most effective vaccine to prevent equine infectious anemia in the world. According to the statistics of the Ministry of Agriculture, the application of this vaccine saved the country 6.5 billion yuan in economic losses in 10 years.
1983, the international conference on equine infectious anemia was held in Harbin. In the same year, the American Veterinary Association invited Shen Rongxian to attend the 120 Veterinary Annual Meeting held in new york, which was supposed to be attended by only Americans. Foreign scholars marvel: "China's equine infectious anemia vaccine will save thousands of horses' lives. "
The successful development of equine infectious anemia vaccine has brought hope to the prevention of AIDS. He said: "My greatest wish is to promote the scientific research process to overcome AIDS ..."
1984 after the discovery of HIV, scientists began to study AIDS vaccines. Now, more and more virologists believe that it is a more comprehensive, scientific and reliable route to find a successful vaccine of the same kind-equine infectious anemia vaccine, and to study its immune protection mechanism in depth, and then apply its principles to guide the research of AIDS vaccine.
Equine infectious anemia vaccine contains important information about the immune protection mechanism of lentivirus-AIDS virus, which has attracted much attention in the world. These important information have been verified in animals by molecular cloning of vaccine strains. The successful development of equine infectious anemia vaccine makes it possible to study AIDS vaccine. The New York Times once reported in a large space: "The successful development of equine infectious anemia vaccine in China brings hope for AIDS prevention and treatment."
At the beginning of 1997, under the impetus of Academician Shen Rongxian, Harbin Veterinary Research Institute reached an international cooperative research agreement with the United States, the Netherlands and other three countries, which not only provided an animal model for the attenuated vaccine for AIDS, but also created conditions for promoting the attenuated vaccine for equine infectious anemia to the world. At the beginning of 1999, Harbin Veterinary Research Institute and AIDS Reference Laboratory of Chinese Academy of Preventive Medicine made a breakthrough in the cooperative research on molecular biology of equine infectious anemia virus.