On June 29th, the reporter went to the Human Genome Center of Institute of Genetics, Chinese Academy of Sciences, which undertook the main sequencing task of "1%".
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And interviewed Professor Yang, Executive Chairman of China Human Genome Project, and Wang Jian, Executive Director of the Center. They told reporters in detail about China's commitment to human genome project 1% sequencing.
"1%" is a century's struggle.
Targeting the human genome project
In Area B of Beijing Shunyi Airport Industrial Park, there is an inconspicuous four-story building, in which the Human Genome Center of Institute of Genetics, Chinese Academy of Sciences is located. This center was founded by four international students with the support of Chinese Academy of Sciences. Its director, Yang, is the Secretary-General of the National Natural Science Foundation of China Major Human Genome Project and a member of the International Bioethics Committee of UNESCO. Wang Jian, executive director, once did postdoctoral research at the University of Texas. Yu Jun is a major researcher in the mainstream research field of human genetic engineering in the United States. Liu Siqi is an assistant professor at the University of Louisville. Yu Jun and Liu Siqi are still overseas, engaged in human genome research. These four international students came together for China to participate in the Human Genome Project. Previously, they were either old classmates or old acquaintances, and they were close friends for many years.
At the beginning of 1994, Yang, who had done postdoctoral research in France and the United States, returned to China as a professor and doctoral supervisor of Peking Union Medical College. At this time, under the appeal of academicians such as Wu Hao and Zhu Chen, the domestic scientific community demanded that China actively participate in human genetic research. Soon, Yang's friend Wang Jian returned to China to start a business. From 65438 to 0996, Yu Jun, a friend Wang Jian met in America, returned to China to "visit relatives". Yu Jun began to participate in human genome research in the United States from 199 1. This time, he is looking for the possibility of bringing the idea and technology of genetic research back to China. After many twists and turns, he contacted Wang Jian and Yang. They began to brew into the human genome project.
10, the first meeting of the Youth Committee of the Chinese Genetic Society was held in Zhangjiajie. At this meeting, Yang, Wang Jianhe got together to discuss the human genome project. Yu Jun said that if China doesn't take the time to join the competition, it may lose its last chance.
Fuck, they decided to join hands to promote this cause.
However, it was too difficult to do it, because there were too few people who knew about the human genome project in China at that time, and they didn't get real support. 1March, 998, Professor chen shouyi, director of Institute of Genetics, Chinese Academy of Sciences, found Wang Jian, and the two sides hit it off. Yang and Wang Jian decided to "take root" in Chinese Academy of Sciences. 1In August, 1998, with the support and help of the leaders of China Academy of Sciences, the Genome Center of Institute of Genetics of China Academy of Sciences was established, with Yang Ren as the director.
China won "1%"
The calendar of 1999 is already open. Yang said that if we want to do it, we must make it bigger, no matter how difficult it is. As a result, Yang, Wang Jian and three people pooled their savings by more than 2 million yuan. They used the money to buy a "377" sequencer and an American-made capillary sequencer. In less than half a year, they submitted the sequencing results of 700,000 bases of the human genome sequence and sequenced the hot spring bacteria. These achievements have attracted the attention of international counterparts.
During this period, the international debate about whether the gene sequence can be patented began to be fierce. Serila Company, founded in May, 1998, runs counter to the public funds for gene sequencing, relying on the support of consortia and advanced equipment, hoping to take the lead in measuring data and win patents. If the gene sequence is allowed to be "patented", it means that the first big company can monopolize the rights of related products developed with these genes in the future. Yang, a member of UNESCO's International Bioethics Committee, lobbied everywhere: "Human beings have only one genome, which represents the consistent information of all mankind. Data should be open and shared for free, which should be the premise of research. "
Scientists who uphold justice realize that in order to compete with private enterprises for gene patents, we must speed up sequencing.
On June 23rd, 1999, Yang and Wang Jian received an email from, which explained the current competitive situation of the international human genome project. On that day, they had a serious communication.
"If we want to do it, we must do 1%. What are we afraid of? We have the power. Our previous work shows that we can achieve 1%. " Yang said to him.
"Well, even if you sell iron in a saucepan, you should circle 1%." Wang Jian shook his fist.
Their opinions were supported by the leaders of the Chinese Academy of Sciences and colleagues from the North-South National Genome Center, and then by mainstream international scientists. The Human Genome Center of the Institute of Genetics, China Academy of Sciences applied to the National Institutes of Health. On July 8th, the website of Human Genome Project announced that "1%" was successfully applied in China. After the United States, Britain, France, Germany and Japan, China became the sixth participant in the Human Genome Project.
China won the opportunity.
China's "1%" task is located on chromosome 3. The incidence of nasopharyngeal carcinoma is high in southern China, and the related gene is on chromosome 3.
The Human Genome Center of the Institute of Genetics found an empty factory building in the Airport Development Zone. It is difficult to transform the factory building into a laboratory and increase the equipment.
The Chinese Academy of Sciences sent people to help, and Yang's hometown Wenzhou sent people to help ... In more than a month, the laboratory was built and the 14 sequencer was purchased. On September 1, at the 5th Human Genome Sequencing Strategy Conference held in London, on behalf of the Center, Yang announced that he would ensure the completion of the "all-in-one" regional task and reach "more than half of the sequences" by the end of the spring of 2000.