Pegylated interferon is a long-acting interferon formed by the combination of recombinant human interferon α2b (hereinafter referred to as common interferon) and polyethylene glycol (40kD Y type).
Interferon can bind to the specific α -interferon receptor on the cell surface, trigger the complex signal transduction pathway in the cell and activate gene transcription, regulate a variety of biological effects, including inhibiting virus replication and cell proliferation in infected cells, and have immunomodulatory effects. This product has antiviral and antiproliferative activities of non-PEG-bound α -interferon (common interferon) in vitro.
Extended data:
Interferon is highly species-specific, so animal interferon is ineffective for humans. Interferon has anti-virus, cell proliferation inhibition, immunomodulation and anti-tumor effects.
It is mainly used to treat advanced hairy cell leukemia, renal cancer, melanoma, Kaposi's sarcoma, chronic myeloid leukemia and moderate and low grade malignant non-Hodgkin's lymphoma. Others have been used for osteosarcoma, breast cancer, multiple myeloma, head and neck cancer and bladder cancer. It is also suitable for acute and chronic viral hepatitis C and chronic active hepatitis B.
Adverse reactions are mainly flu-like symptoms such as fever, fatigue, myalgia and headache. Followed by mild myelosuppression. Generally, it has no effect on liver and kidney function, and a few have elevated transaminase and serum creatinine.
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Baidu Encyclopedia-Pegylated Interferon α2b Injection