1, vaccine production methods are different.
Inactivated vaccine is a pathogen with strong immunogenicity. After artificial culture and physical and chemical inactivation, it cannot be produced without "live virus".
However, the concept of "inactivation" does not exist in genetically engineered vaccines. It only needs to carry COVID-19 nucleic acid fragments and send them into cells like a car to stimulate immunity.
2. Different ways to produce immunity.
Inactivated vaccine needs multiple vaccinations, and its immune effect has certain limitations. Dead vaccines mainly induce the production of specific antibodies, that is, basically only humoral immunity will be produced.
The genetically engineered vaccine injected into the human body through treatment will cause some immune reactions, and make the body produce antibodies or memory cells against this antigen to achieve immune effect.
Extended data
Novel coronavirus vaccine (20 19-nCoV vaccine) is aimed at novel coronavirus.
The general process and cycle of vaccine research and development includes two stages:
The first stage is the pre-research and development of vaccine, including obtaining immunogen (obtaining live virus, separating related subunits, obtaining recombinant protein or synthesizing related DNA(RNA) through gene recombination technology, immune response test, animal protection test, optimization of immunogen production process (amplification), preclinical toxicology research and so on.
The second stage is the process of vaccine development and registration, including preclinical research, clinical application and clinical trials, and finally the vaccine can be listed.
References:
Baidu Encyclopedia-COVID-19 Vaccine