Which reagent should be used to block TLR4 signal, pmb or tak242?

1.pmb binds to LPS, the activator of TLR4, thus blocking and only blocking the activation of TLR4 signal pathway caused by LPS, but not really inhibiting TLR4.

Secondly, tak242 specifically blocks TIR Toll/IL- 1 receptor in the intracellular domain of TLR4, without affecting the extracellular docking with its main ligand LPS. Therefore, TAK-242 inhibits the intracellular signal transduction of TLR-4 and prevents it from binding to its adapter molecules.

Personally, I think TAK-242 may be more useful.