1. Prevention of HPV subtypes
Whether it is an imported or domestic bivalent HPV vaccine, the subtypes it prevents are HPV16 and HPV18
Two types of HPV The vaccines are all approved to prevent cervical cancer and cervical cancer in situ caused by infection with HPV16 and 18.
The instructions for the imported bivalent HPV vaccine mention that it is effective against HPV31/33 and 45 It has a cross-protective effect, but there is no evidence that it can prevent related diseases caused by several HPV subtypes
2. Antibody persistence
Antibody persistence for HPV16 and HPV18 , there is not much difference between the two vaccines
Among them, the HPV16 antibody positivity rate of Chinese-made Xinconin can reach 100% at 66 months after vaccination, while the imported Cervarix can reach 100% at 60 months after vaccination. The positivity rate of HPV16 was also 100%, which dropped to 99.6% by the 72nd month.
In terms of HPV18 antibody persistence, the domestic Xinconin was 98.3% after the 42nd month, and the imported Cervarix It is 99.3% after 48 months of vaccination;
Because the sample data age group and value time are different, the data will be slightly different~
If it seems to be more troublesome, The editor will help you summarize: the two are basically the same in terms of antibody concentration and persistence of HPV16 and 18 types
3. Other comparisons
Expression system:
< p>The two bivalent HPV vaccines are both recombinant human papillomavirus vaccines. Cervarix uses an insect cell expression system, while Xingconin uses an Escherichia coli expression system, which has high production capacity and low cost, so the price is lower.Characteristics:
Domestic bivalent is packaged in vials, and imported bivalent is prefilled packaging
Generally speaking, imported bivalent and domestic bivalent HPV There was little overall difference in the vaccines.
4. Price analysis
The price of domestic Xinconin is about 350 yuan per shot, and the imported Xinconin is about 605 yuan per shot. Therefore, relatively speaking, the price of domestically produced 2 The price/performance ratio will be higher, but the domestic 2-price drug has not been on the market for a long time, and it will take time to verify the long-term immune maintenance effect.
However, the domestic 2-price HPV vaccine has not yet been launched in large quantities, and some cities are not yet covered, so it is not easy to make an appointment. It is recommended that no matter which vaccine you choose, the sooner you get vaccinated, the sooner you will be protected, and it is cost-effective. The higher.