The examination of obvious substantive defects in an application for a patent for invention mainly includes whether it belongs to the circumstances stipulated in Article 5 (violation of national laws and social ethics) and Article 25 (types of patents not granted) of the Patent Law, and whether it obviously does not conform to the circumstances stipulated in Article 2, paragraph 2 (not belonging to the technical scheme), Article 26, paragraph 5 (explanation of the source of genetic resources), Article 31, paragraph 1 (non-uniformity) and Article 33 (modification of application documents is beyond the scope) of the Patent Law. Whether to conduct confidentiality review belongs to the content of formal review.