In foreign countries, SOD is often used to monitor the secondary (free radical) peroxide damage caused by ischemia, hemorrhagic heart, brain and other important organ diseases (or after surgical treatment) and the therapeutic effect of free radical scavenging drugs, so as to guide the clinical formulation of corresponding free radical scavenging intervention countermeasures and establish the best treatment time window, which has important reference value for the diagnosis of secondary free radical injury, the follow-up of free radical scavenging treatment efficacy and the judgment and evaluation of prognosis.
The consensus is that SOD determination is a non-specific auxiliary diagnostic index, but it has important reference value for real-time dynamic monitoring of free radical metabolism disorder, intervention measures of free radical scavenging, and judging the course outcome of patients with the same disease (aggravation or alleviation of free radical damage, free radical scavenging drugs or surgical treatment effect).
1, SOD level decreased:
First, the physiological decline:
Insufficient intake of antioxidant nutrients such as vitamin E, VitA, VitC, β-carotene, selenium, copper, zinc and manganese. Selenium is a component of GSHPx, copper and zinc are components of Cu/Zn-SOD, and manganese is a component of Mn-SOD.
Generally speaking, the activity of scavenging enzymes in the elderly is reduced, the metabolic function of the elderly is reduced, the enzyme-induced production is reduced, and the dynamic balance of low-concentration free radicals cannot be maintained.
B, pathological reduction:
Cerebrovascular diseases: acute cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, HIE (hypoxic ischemic encephalopathy), trauma: craniocerebral injury.
Ischemic heart disease myocardial ischemia (coronary atherosclerotic heart disease), acute myocardial infarction
Secondary injury after medical operation, ischemia-reperfusion injury (IRI), systemic circulation disorder, etc. will cause reperfusion injury after the blood supply is restored: the release of shock microcirculation spasm, cardiopulmonary resuscitation after cardiac arrest, and the establishment and release of cardiopulmonary bypass (for example, myocardial ischemia-reperfusion injury may be caused after the blood supply is restored after cardiopulmonary bypass in heart surgery).
Reperfusion injury caused by blood flow recovery or recanalization of a certain tissue or organ after ischemia, such as arterial bypass grafting, percutaneous transluminal coronary angioplasty, thrombolytic therapy, organ transplantation, replantation of severed limbs, and release of coronary artery spasm.
Peroxide damage after hyperbaric oxygen (HBO) treatment and peroxide damage after radiotherapy: radiation encephalopathy;
2.SOD level increased.
First, physiological increase:
If excessive SOD is added exogenous for a long time, the body will not be able to maintain a certain level of free radicals. Immune cells use free radicals as a method to perform their immune functions. Too low free radicals will cause abnormal physiological and biochemical processes, destroy normal physiological functions, such as detoxification, decreased phagocytosis, blocked coagulation process and impaired synthesis of collagen, prostaglandin and cyclic nucleotide, and cause serious toxic and side effects.
B, pathological increase:
Studies at home and abroad show that in the early stage of acute disease, when the free radicals in the body increase in large quantities, the body will quickly cause oxidative stress, affecting the expression of protein and other regulatory and reaction mechanisms. Under the induction of free radicals and the compensatory stress of the body, cells or bodies will enhance their antioxidant capacity, and generally there will be a temporary increase in SOD level.
However, with the large consumption of SOD by high concentration free radicals and the imbalance of compensation, the biosynthesis ability of SOD will soon fall back to a lower level and maintain a new dynamic balance with higher concentration free radicals.
3. Clinical monitoring: 20 12 In order to improve the inspection items and better serve the clinic, the biochemical room of the clinical laboratory of Chancheng Central Hospital recently carried out the detection of superoxide dismutase (SOD).
Extended data:
Side effects of superoxide dismutase: occasional local pain, urticaria and proteinuria after intramuscular injection.
The basic principle of superoxide dismutase: SOD belongs to metalloproteinases. According to the different kinds of bound metal ions, there are three kinds of superoxide dismutase: Cu-ZnSOD, Mn-SOD and Fe-SOD. These three kinds of SOD catalyze superoxide anion free radicals and convert them disproportionately into hydrogen peroxide and oxygen.
The free radicals in superoxide dismutase will do a lot of harm to the body, but in general, there are also systems for scavenging free radicals and inhibiting free radical reactions in human cells, some of which belong to antioxidant enzymes and some belong to antioxidants. For example, SOD is a main antioxidant enzyme, which can scavenge superoxide radicals and play an important role in preventing oxygen poisoning, inhibiting senile diseases and preventing aging.
SOD can specifically remove harmful free radicals in the body, thus alleviating the harm caused by free radical oxidation of some components in the body. Such as oxygen poisoning, acute inflammation, edema, autoimmune diseases, radiation diseases and other diseases are all related to the toxicity of active oxygen. Experiments show that SOD can eliminate free radicals, so it can eliminate the causes of the above diseases.
Clinical application: At the product release conference of "Modern Agricultural Science and Technology Project-Experimental Research on Selenium-enriched SOD and High Calcium Grape Successfully" held on August 8th, 20th/KLOC-4th, it was developed by the expert group of three kinds of agricultural products (quality, nutrition and function) of Southwest University Old Professors Association, supervised by the Institute of Plant Ecological Engineering of China Agricultural University, and the selenium-enriched SOD and high calcium grapes jointly developed and produced by Chongqing Maoshuihu Fruit Planting Cooperative were officially unveiled.
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