On the homepage of the Nobel Prize (www.nobelprize.org), it is also clearly pointed out that the reason why he won the prize is "because his work is biochemically called an important sulfur compound, especially because of First Synthesis Isopeptide Homone". Compared with VincentduVigneaud, Chinese scientists have no essential breakthrough and innovation in the method of synthesizing bovine insulin, which fundamentally determines that our work cannot be awarded the Nobel Prize!
On the contrary, American chemist RobertBruceMerrifield won the Nobel Prize in Chemistry from 65438 to 0984 because he invented the solid-phase synthesis of peptides, which was a major breakthrough in methodology. The home page of the Nobel Prize also points out that the reason for winning the prize is "for the development of methodology". It can be seen that the most important thing for the Nobel Prize is the breakthrough and innovation in essence.
Secondly, from the physiological point of view, bovine insulin is not the first artificially synthesized bioactive polypeptide or protein. Before this, other peptides between bovine insulin and oxytocin have also been synthesized. After it, peptides with larger molecular weight were synthesized one after another. Oxytocin, the smallest polypeptide, has won the Nobel Prize, and the record of "the largest" is still being refreshed, so it is impossible for the former record of bovine insulin in the middle to win the Nobel Prize. Otherwise, in the field of physics, every time a new element is synthesized artificially, won't it win the Nobel Prize in physics? !
In fact, what China really missed the Nobel Prize was Zhao Zhongyao's discovery of positrons in the late 1920s. Many people have commented on this matter, so I won't say much here.
In the final analysis, except for a few mistakes, the Nobel Prize is awarded to those research achievements that have essential breakthroughs and innovations in methods and can have a far-reaching impact in major fields.