The content of water-soluble florfenicol is divided into 10%, 20%, 30%, 50%, 70% and 90%. In order to solve the water solubility of florfenicol, it is developed with special cosolvent and advanced technology. It solves the problems of drinking water for livestock and poultry and medicated bath for aquatic animals, and has the same function as raw materials, but higher bioavailability. It is an ideal drug for treating bacterial diseases of livestock and poultry and aquatic animals, with good effect and wide indications.
This paragraph edits 70% water-soluble florfenicol.
Basic features:
The main component is florfenicol.
70% water-soluble florfenicol
Properties This product is white or white-like powder, soluble in water.
Pharmacological action This product is a broad-spectrum antibacterial agent, which strongly interferes with the synthesis of bacterial protein. Quickly absorbed and widely distributed in the body,
Long half-life, no side effects of aplastic anemia, no drug resistance, no residue and no cross-drug resistance, so it is a substitute.
Chloramphenicol and thiamphenicol are a new generation of chloramphenicol antibiotics.
Indications are mainly used for bacterial diseases and mycoplasma infections in pigs, chickens and fish caused by sensitive bacteria, as well as large intestine of livestock and poultry.
It has unique curative effect on diseases caused by Bacillus, porcine contagious pleuropneumonia and wheezing.
Usage and dosage: mixed feeding: livestock and poultry 1g mixture 10-20kg, free to eat. Double it for the first time and feed it continuously 1 week.
Drinking water: livestock 1g, water 10-20kg, free to drink. 1 week. Double the first time, and halve the prevention.
The withdrawal period is 30 days.
Precautions 1. Use with caution in pregnant animals. 2. This product does not cause aplastic anemia, but it may cause short-term anorexia and drinking in cattle after use.
Adverse reactions such as decreased water and diarrhea. 3. Do not use it with drugs such as β-lactams, aminoglycosides and rifampicin.
Use.
Florfenicol series
Packing specification10kg, 25kg
Experimental report:
Comparison of florfenicol sodium succinate type I and florfenicol sodium succinate type II microcapsules:
Product name PH content/%process characteristics Product advantages and disadvantages Application description
Florfenicol sodium succinate type I
(domestic patent No.200810015571in Meng Hui, Jinan) 7 ~ 8 ≥ 95% chemical synthetic solution is unstable, easy to deliquesce and agglomerate, so it is forbidden to be compatible with doxycycline hydrochloride.
Florfenicol sodium succinate type Ⅱ
(microcapsule coating) 4~6 ≥98% chemical synthesis, microcapsule coating solution is released stably and slowly, not affected by PH value and water temperature, and can be compounded with doxycycline hydrochloride, tylosin, neomycin sulfate and TMP lactate without caking.
Indications: chicken colibacillosis and duck serositis, as well as intestinal and respiratory diseases caused by mycoplasma in cattle, pigs and sheep.
Usage and dosage: mix and drink, and take according to the effective amount. Poultry: 5g/ 100kg water.
Features: not affected by water temperature, completely dissolved, quickly absorbed, and high biological potency.
Jinan Meng Hui Biotechnology Co., Ltd. launched strongly.
If you need the formula, please ask our company for it.
The properties of various water-soluble florfenicol are compared as follows:
Product name content% solubility/100ml dissolution shall be noted according to the combination method.
Chemical synthesis of florfenicol sodium succinate (initiated by Jinan, Meng Hui)
PatentNo.: 200810015571) ≥ 95100000 instant powder injection (colorless and transparent)
physical method
(Domestic status) PEG6000 dispersion ≤ 1037.05438+0 is taken orally slowly.
physical method
(Domestic status) PVPK dispersion ≤30 14.39 slow oral administration.
physical method
(Domestic status) Polysaccharide dispersion ≤ 10 39. 12 is slow oral administration.
physical method
(Domestic status) β -cyclodextrin inclusion ≤25 9320 slow oral administration (flocculation)
physical method
(Domestic status) The inclusion rate of hydroxypropyl β -cyclodextrin is ≥44 46300, and the price is fast.
The second generation cosolvent of Jinan Meng Hui Biotechnology Co., Ltd. ≥70 200 is fast, clear and transparent.
This paragraph edits 90% water-soluble florfenicol.
Florfenicol has many practical values, but there is still a problem to be solved, that is, it is insoluble in water, its utilization rate is low, and its efficacy cannot be fully exerted. This problem has not been well solved. At present, the water-soluble technology of florfenicol in China is physical methods: cosolvent micronization, β -cyclodextrin inclusion, hydroxypropyl β -cyclodextrin inclusion, PVPK dispersion, PEG6000 dispersion, ultramicro, grinding and other methods are generally unsatisfactory, and the dissolution rate is slow and the dissolution amount is small, which is difficult to meet the needs of preparations and concentrated preparations. Our company adopts the most advanced chiral synthesis technology in the world, and uses D- Su -2- amino-1- (p-methylsulfonyl) phenyl-1.3- propanediol as raw materials to synthesize florfenicol under the action of chiral organic zinc and YH-3 catalyst. The water solubility is fast, and the biological activity of florfenicol is enhanced after it enters animals. Conduct clinical trials. Duck serositis; The therapeutic effect on pig asthma and piglet yellow and white dysentery is better than that of florfenicol, which successfully solves the problems that have not been solved in academic circles.
90% water-soluble florfenicol (chiral synthesis)
Its characteristics: 1. It is not affected by water temperature, completely dissolved and absorbed quickly, and its biological titer is as high as 65438+ 0.5 times that of common water-soluble florfenicol.
2. Unique optical molecular structure, not easy to produce drug resistance, regulating immune cytokines and inflammatory signal transduction pathway.
3. Inhibit bronchospasm and antiallergic, and have obvious effect on respiratory tract.
Note: It is forbidden to use with alkaline drugs.
Production company: Jinan Meng Hui Biotechnology Co., Ltd.
Address: No.2 Maanshan Road, Jinan.
Edit this water-soluble florfenicol instruction manual.
major constituent
florfenicol
Character; Role; letter
This product is white or white-like powder, soluble in water.
pharmacological action
This product is a broad-spectrum antibacterial agent, which strongly interferes with the synthesis of bacterial protein. It has the advantages of fast absorption, wide distribution in vivo, long half-life, no side effects of aplastic anemia, no drug resistance, no residue, no cross-resistance and so on. It is a new generation of chloramphenicol antibiotics instead of chloramphenicol and thiamphenicol.
indicate
It is mainly used for bacterial diseases and mycoplasma infections in pigs, chickens and fish caused by sensitive bacteria, and has a unique curative effect on diseases caused by Escherichia coli in livestock and poultry, contagious pleuropneumonia in pigs, wheezing and so on.
dosage
Mixed feeding: livestock and poultry products 1g mixture 10-20kg, free to eat. Double it for the first time and feed it continuously 1 week.
Drinking water: livestock 1g, water 10-20kg, free to drink. 1 week. Double the first time, and halve the prevention.
(Provided by Jinan Shanpeng Economic and Trade Co., Ltd.)
Edit the comments in this paragraph and other paragraphs.
under the influence
30 days
Matters needing attention
1. Use with caution in pregnant animals. 2. This product does not cause aplastic anemia, but may cause short-term adverse reactions such as anorexia, decreased drinking water and diarrhea. 3. Please do not use it together with β-lactams, aminoglycosides, rifampicin and other drugs.