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Which anti-wrinkle skin care products are good
First of all, do you understand what wrinkles are?
Intuitively, it is a concave and convex stripe on the skin. As people age, their skin will gradually age. The skin is affected by the external environment and forms free radicals. The free radicals destroy the collagen and active substances in the normal cell membrane tissue and oxidize the cells to form fine textures, which are called wrinkle. Wrinkles generally appear in the order of forehead, upper and lower eyelids, outside of eyes, preauricular area, cheeks, neck, jaw, and perioral area as we age. Because wrinkles appear in different locations, they are also called different names, including expression lines, crow's feet, nasolabial folds, neck lines, eye bag lines, etc.
The principle of TOOFOB:
Natural therapy, through the guidance of simulated skin scabs, activates the body's own repair function and naturally repairs metabolic shrinkage cells and aging cells.
The French TOOFOB expert team discovered through a large number of clinical medical studies that when human skin tissue is damaged, scabs will form on the surface of the damaged area. Scabs are the beginning of the process of cell tissue repair and represent the formation of scabs. There is continuous natural repair activity in the covered area until the scab falls off.
TOOFOB is a biological skin made based on the principles of human bionics. It can repair fine lines 24 hours a day and 3-year-old lines within 7 days. TOOFOB contains essential cell growth factors and repair factors. After using TOOFOB, the human body will automatically recognize that the TOOFOB area is a wound scab and quickly start the autologous repair process. Orderly capture atrophic cells, damaged cells, senescent cells and mutated cells for targeted repair and update. The essential growth factors and repair factors contained in its ingredients provide nutritional support for repairing and generating new cells. Clinical data shows that TOOFOB's main applicable area is the improvement of wrinkles.
TOOFOB wrinkle repair patch ingredients-detailed explanation of repair factors:
1. TOOFOB fibroblast/dermal growth factor (AFGF)
can drive the growth of skin cells. Accelerate tissue repair and promote cell healing. Two peptides: can promote cell healing and resist oxidation, and have excellent anti-aging effects. AFGF is a multifunctional and powerful cytokine that plays an important role in promoting the metabolism of fibroblasts and the formation of collagen.
AFGF can promote the growth and reproduction of skin tissue. By binding to specific receptors on the cell surface, it regulates the division, reproduction, growth and differentiation of skin epithelial, endothelial and stromal cells, promotes cell metabolism and enhances oxidation; It can promote the rapid growth and reproduction of cells related to skin damage, and regulate the synthesis, secretion and decomposition of intercellular matrix; it can promote the regeneration of stratum corneum cells, accelerate the repair of skin stratum corneum and matrix layer, and promote the growth of human skin cells; it can Enhance the protein synthesis and cell metabolism of skin cells, delay the aging of skin cells, promote the repair and growth of epidermal cells, and make the skin smooth and plump.
FGFs is a protein family composed of 23 members (FG-FI-FGF2301). It plays an important role in promoting the growth and development of the body and repairing tissue damage.
Promote the generation of new cells to replace the original cells. Mechanism: AFGF can actively bind to specific receptors on the cell membrane near the wound. Thereby promoting cell division and reproduction, repairing wounds quickly and efficiently,
2. TOOFOB stem cell growth factor (HGF)
Hepatocyte growth factor is present in the plasma of animals with acute liver injury. A protein factor that can stimulate DNA synthesis in liver cells. HGF not only plays a role in liver regeneration, but also plays an important role in regulating the growth and differentiation of many tissues and cells.
HGF can stimulate vascular endothelial growth factor (VEGF), significantly increase the mRNA expression and transcriptional activity of ets-1, regulate the initiation of cell regeneration, and promote cell division.
HGF has a function similar to spreading factor (sF). Adding different concentrations of HGF to some epithelial and endothelial cell culture systems can promote cell diffusion and migration. Protect and repair endothelial cell function. When endothelial cells are damaged, the endothelial structure or function is damaged, and subendothelial collagen, microfibers, etc. are exposed. HGF resists endothelial cell apoptosis. In vitro studies have shown that HOF can pass (ERK)/STAT3 and Silk/Su It exerts anti-endothelial cell apoptosis through the activation of signal transduction pathways such as Akt.
HGF can repair endothelial cells by activating the nitric oxide synthase (NOS) system. Studies have shown that HGF can affect the expression of endothelial cell nitric oxide synthase (eNOS). This in turn leads to the phosphorylation and activation of eNOS and repairs endothelial cells. HGF promotes DNA synthesis in endothelial cells, and the DNA synthesis stimulated by HGF is significantly stronger than basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), promoting angiogenesis: increasing tissue blood supply.
3. TOOFOB nerve growth factor (NGF)
Human nerve growth factor is a protein. It is available in many animals. Nerve growth factor can regulate the growth of peripheral and central neurons. Growth and development, maintaining the survival of neurons. It plays an important regulatory role in the development, differentiation, growth, regeneration and expression of functional properties of central and peripheral neurons.
NGF is mainly distributed in the human body in the brain, ganglia, iris, heart, spleen, placenta and other tissues, as well as fibroblasts, smooth muscle, skeletal muscle, glial cells, Schwann cells, etc. It can repair nerve damage, stimulate nutritional sympathetic and sensory neurons, and achieve a harmonious effect on the skin.
4. TOOFOB keratin growth factor (KGF)
KGF is produced by mesenchymal cells and specifically acts on epithelial cells; it participates in the development of tissues and organs; it participates in skin and epithelial cells Damage repair; damage protection function. Keratinocyte growth factor (KGF-2) is a basic protein growth factor secreted by human subcutaneous tissue cells. It can specifically stimulate the metabolism of epithelial cells and other physiological processes, including cell regeneration, differentiation and migration. KGF is transmitted by epidermal signals and initiates the expression of genes involved in division and growth in epithelial cells, thus stimulating the metabolism of epithelial tissues.
Cytokines with biological effects such as EGF, bFGF, aFGF, TGF, VEGF and PDGF are normal components of human cells and play an important role in the growth, differentiation, regeneration and migration of skin tissue cells. Physiological function, it can stimulate the growth and division of new or aging epithelial cells.
5. TOOFOB Transforming Growth Factor (TGF)
TGF-β is named based on the fact that this cytokine can transform the phenotype of normal fibroblasts, that is, in In the presence of epidermal growth factor (EGF) at the same time, it changes the growth characteristics of the inner wall of fibroblasts and acquires the ability to grow in agar. TGF-β3 is mainly produced by cells of mesenchymal origin. TGF-β plays a role in wound healing and promotes cartilage and bone repair. TGF-β has a stimulatory effect on cells of mesenchymal origin and an inhibitory effect on cells of epithelial or neuroectodermal origin. Regulation of cell phenotype, promoting the growth of fibroblasts, osteoblasts and Schwann cells.
TGF-β1 and TGF-β2 promote the production of IL-6 in human fibroblasts, and the mechanism may be through the regulation of IL-6 gene transcription. Inhibits the growth of epithelial cells, osteoclasts, endothelial cells and the formation of fat, cardiac muscle and skeletal muscle. TGF-β can antagonize some biological functions of EGF. Promote the expression of extracellular matrix (ECM) such as collagen and fibronectin and inhibit the degradation of ECM.
6. TOOFOB Vascular Endothelial Growth Factor (VEGF)
The vascular endothelial growth factor gene consists of 8 exons and 7 introns. Currently, VEGF is the target At this point, medical applications are developing in two directions: promoting the regeneration of microvessels around new cells, providing more nutrients, repairing vascular endothelium, and accelerating tissue repair.
7. TOOFOB Fibroblast Growth Factor (BFGF)
Data show that bFGF has an extremely wide range of biological effects, repairing and consolidating fibroblasts and helping skin blood circulation.
It plays a very important role in blood vessel formation, promoting wound healing and tissue repair, promoting tissue regeneration and the growth and development of nervous tissue.
bFGF is a mitogenic cationic polypeptide that has a chemotactic effect on single cells. As a mitogen, bFGF mainly acts on skeletal muscle cells, fibroblasts and cells originating from mesoderm and neuroectoderm. Osteocytes etc. bFGF accelerates cell phase transition, stimulates enhanced DNA synthesis of cells, and promotes cell division and proliferation.
The biological effects of bFGF are divided into two parts: in vivo and in vitro. The effect in the body is very strong, and it has strong cell division and proliferation activity in fibroblasts, osteocytes, chondrocytes, vascular endothelial cells, adrenal cortex and medullary cells, neurons and glial cells.
bFGF is an important mitogenic factor. Its main biological functions are: (1) serving as a vascular growth factor; (2) promoting wound healing and tissue repair; (3) promoting tissue regeneration; (4) Participate in nerve regeneration, etc.
In research on peripheral nerve injury repair, data show that bFGF promotes the regeneration of peripheral nerve fibers, promotes the differentiation of neural precursor cells, and promotes angiogenesis to affect the development of the central nervous system and the peripheral nervous system.
In 1986, he won the Nobel Prize, the highest award in human sciences
8. TOOFOB-like insulin growth factor (IGF)
The full name of IGF-1 It's called insulin-like growth factor number one. IGF-1 is also known as a "growth-promoting factor." It is important in the growth of infants and its continued anabolic effects in adults.
IGF-1 is known to be an active protein polypeptide substance. It is an autocrine and paracrine product of more than a dozen cells in the human body, including liver cells, kidney cells, and spleen cells (that is to say, human The body itself contains IGF-1).
Its specific functions include: lowering blood sugar, lowering blood lipids, relaxing blood vessels, promoting bone anabolism,
Promoting growth: IGF-1 is a very important cell mitosis promoter in the human body .
Promote cell differentiation: IGF-1 is very important for maintaining protein levels related to cell differentiation. Combined with some growth factors, it can promote cell differentiation and maturation.
Wound repair: IGF-1 is also involved in the process of wound healing. Experiments have shown that the concentration of IGF-1 increases in damaged nerve, muscle and skin cells.
It can effectively promote fat metabolism, synthesize collagen and elastic fibers, and smooth fine lines and wrinkles.
9. TOOFOB platelet-derived growth factor (PDGF)
Platelet-derived factor (PDGF) can promote the activation of subcutaneous microvessels, and monocytes/macrophages in the body are the main cells that synthesize PDGF.
Under physiological conditions, PDGF is stored in platelets in the form of α-granules. When cells are damaged, both endothelial cells and activated hepatic stellate cells can secrete PDGF. Acts in an autocrine and paracrine manner.
PDGF must bind to the corresponding receptor on the cell membrane to exert its biological effects. The PDGF receptor is a transmembrane glycoprotein with tyrosine protein kinase activity. When the receptor binds to its ligand, it prompts the two receptor molecules to form a dimer and activates the autophosphorylation of tyrosine residues in the intracellular domain. Phosphorylation, or phosphorylation of tyrosine residues that activates special target proteins, thereby transmitting signals into cells, and regulating cell life activities through a cascade amplification waterfall effect, including the division and proliferation of target cells.
Experiments have proven that PDGF is an important mitogenic factor and has the ability to stimulate the division and proliferation of specific cell groups. The secreted PDGF stimulates interstitial astrocytes to proliferate and transform into myofibroblasts, and promotes astrocyte migration and accumulation in the damaged area. Myofibroblasts synthesize a large amount of extracellular matrix and deposit it in the interstitium of liver cells, promoting liver fibrosis. PDGF can promote myofibroblasts to produce collagen, especially type I and type III collagen. The mother cells proliferate, causing the fused cells to produce collagen, but this has no effect on their cell number. PDGF can also inhibit the action of collagenase by upregulating tissue inhibitor of metalloproteinases (TIMP-1) to reduce the degradation of extracellular matrix, repair the subcutaneous blood microcirculation system, and provide sufficient nutrition to the skin. Promote collagen synthesis.
10. TOOFOB Epidermal Growth Factor (EGF)
EGF is an active substance in the human body that stimulates the tyrosine phosphorylation of the epidermal growth factor receptor to achieve repair. Proliferating skin surface cells can promote cell proliferation and differentiation, thereby replacing aging and dead cells with new cells.
EGF can promote the growth and division of various cells in the epidermal cell tissue, making the epidermal cells plump and restore their youthful state. It can also promote the growth of collagen and repair aging and broken collagen elastic fibers. EGF Can promote rapid renewal of human skin.
The scientific discovery of RGF is a combination of natural callus molecule factors. This is a cytokine composition with automatic sensing function and bidirectional regulation. It can accelerate cell proliferation as needed in the early stages of repairing damage. When the repair is close to perfection, it can automatically slow down the rate of cell proliferation.
Experimental studies have shown that EGF can stimulate the proliferation of a variety of cells, mainly epidermal cells and endothelial cells. It has achieved good results in the repair and healing of corneal injuries, burns and surgical wounds. Professors Montalcini and Cohen won the 1986 Nobel Prize in Physiology and Medicine for discovering epidermal growth factor and analyzing its structure and mechanism of action.