Qu Lianghu's Main Research Achievements

The main research results are as follows: 1) the technical system of RNA genome research has been established, and a large number of new small molecular RNA motifs have been found and identified in eukaryotic model organisms such as mammals, plants and yeast. 2) The research of plant RNA genomics has made a breakthrough in the organization and expression pattern of plant RNA genes: 1 1 new SnRNA gene clusters in Arabidopsis thaliana were reported for the first time in the world, and the new gene organization of RNA gene clusters in rice gene introns was discovered, revealing the special organization form and expression mechanism of plant SnRNA genes with gene clusters as the main body. Invited to participate in standardizing the naming system of international plant snoRNA system and building the international plant snoRNA database. 3) Significant progress has been made in the study of structural and functional diversity of SnRNA genes: the structure and function of the first gene cluster composed of seven new SNRNA genes in Saccharomyces cerevisiae were discovered and identified, and the new mechanism of transcription and processing of this gene cluster was clarified. A new SNRNA gene capable of modifying U6snRNA was found and identified in Schizosaccharomyces pombe. Using gene knockout technology, genetic evidence was provided for the first time for SNRNA to guide the post-transcriptional modification of U6snRNA, revealing the post-transcriptional transport process of U6snRNA precursor in the nucleus and the sequence of intron splicing and intramolecular ribomethylation of U6snRNA precursor. 4) Using rRNA technology to study biological resources in special ecosystems, such as marine microalgae and red tide monitoring, gene identification of compound fungus Cordyceps sinensis, and diversity of key groups of anaerobic microorganisms in landfill leachate. , has achieved important results. During his three years in office, he published 42 research papers in domestic and foreign magazines, and 16 papers were included in SCI (impact factor 45 points). Obtained 1 national invention patents.