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Insect-borne flaviviruses cause hemorrhagic fevers in humans and are responsible for high morbidity and mortality worldwide. Jody Hobson-Peters and other researchers at the University of Queensland in Australia have isolated a new flavivirus that infects only the insect cells of Australian mosquitoes. It can be exchanged with structural proteins of other flaviviruses to create chimeric viruses that produce high titers of the protein in insect cells but do not infect human cells. They can be used to efficiently produce vaccines or diagnostic antigens and overcome safety and production barriers of other methods. Chimeric virus platforms could facilitate and potentially accelerate the development of much-needed flavivirus diagnostics and intervention methods.
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