1994~1998, School of Pharmacy, Tongji Medical University, Bachelor's degree
1998~2003, Peking Union Medical College of China & Institute of Medical Biotechnology, Chinese Academy of Medical Sciences, direct PhD
Mainly carry out screening and research of cytokine receptor antagonists
Using recombinant human tumor necrosis factor soluble receptor (sTNFR) as the target to establish its antagonist screening model, using this model to screen The anti-TNFR active fungus 1487, the antagonistic water-soluble small molecules 1487A and 1487B were isolated from its metabolites, and the chemical structures of these two compounds were studied.
Using recombinant type I interleukin 1 soluble receptor (sIL-1RⅠ) as the target to establish its antagonist screening model, and screened Streptomyces 139 with anti-IL-1R activity using this model Research was conducted and the antagonistic polysaccharide 139A was isolated from its metabolites. The chemical structure of polysaccharide 139A was studied (this project was funded by the National Natural Science Foundation of China. Project number: 39670016).
2003-2005, Assistant Researcher, Institute of Medical Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences,
Mainly conducting pharmacodynamic research on polysaccharide 139A (cell level and animal Pharmacological activity), drug development and quality standard research on polysaccharide 139A, obtained national invention patent 2005-2006, School of Pharmacy, Wuhan University, lecturer
Research and development of microbial hangover drugs
2006- , School of Pharmacy, Wuhan University, Lecturer
Study on the pharmacological activity of microalgae polysaccharides, establish a cell model of antihyperglycemic active drugs, and conduct antihyperglycemic, anti-tumor, immune activation and other cell-level activities of Difungus polysaccharides. Screening, from 2007-08-01 to 2010-10-31, participated in the "Research on large-scale separation and modification technology of extracellular polysaccharides from edible and health-care microalgae" funded by 863 (Project No. 2007AA10 Z344),