GPI- glucose 6- phosphate isomerase
200 1 GPI antibody was first discovered. Since then, many countries have studied the diagnostic indexes and drug treatment of GPI antibody for RA (rheumatoid arthritis), digestive tract tumor and lupus erythematosus. However, these reports show that anti-GPI antibody is a specific antibody of non-RA, but not a landmark antibody of RA. However, the concentration of GPI antigen in serum and joint cavity fluid of RA patients increased significantly, and GPI was found to regulate matrix metalloproteinase -3 in tumor cells. The latter is highly expressed in synovial cells, vascular endothelial cells and fibroblasts of RA patients, which can obviously promote bone fragmentation and even lymphocyte proliferation. This indicates that GPI antigen plays an important role in vascular synovial hyperplasia and bone destruction of RA. In view of the low specificity of GPI antigen, Beijia Company made a breakthrough in method research and obtained a national invention patent, which made its clinical application a reality.
RA is a systemic autoimmune disease driven by antigen and mediated by T cells. GPI antigen exists in serum and joint effusion of patients with RA, about 64% of healthy people and patients without RA control. GPI is mainly secreted by T cell system and B lymphocyte system in vivo. A large number of GPI antigens enter the serum and joint cavity, which increases the concentration of GPI in the serum and joint cavity, which is the unique autoimmune function of RA. The high concentration of GPI in RA patients is often accompanied by severe joint function limitation, which suggests that the prognosis is poor or the drugs have not played a certain role in the treatment process. After taking the medicine, the condition of RA patients improved, the concentration of GPI in serum and joint cavity effusion decreased, and the symptoms such as joint swelling and pain were alleviated. GPI concentration in GA patients is positively correlated with joint swelling and pain. There is no correlation with other autoimmune diseases, such as inflammation, tumor and hepatitis. Experimental indexes are of great value for early differential diagnosis of RA diseases and understanding the occurrence, development, treatment and prognosis of diseases, and have significant statistical significance in active and inactive groups of RA.
I hope it helps you! !