Asymmetric Synthesis, Structure and Synthesis of Chiral Natural Products: Adding CaH2 and silica gel to Sharpless oxidation reaction system can accelerate the reaction process without affecting the optical yield; In-situ ring-opening of epoxy alcohol was developed and used to synthesize a series of polyhydroxy amines, polyhydroxy nitrogen, thioheterocycles and polyhydroxy sphingosine. Synthesis of polyhydroxy quaternary amino acid sphingosine E and F by intramolecular ring opening method: Chiral synthesis (including asymmetric synthesis) of racemic hindered aromatic compounds; The absolute configuration of natural products with five-axis chiral characteristics was determined for the first time. It was found that Ni(0)/NaH/Zn/PPh3 reaction system can be used to couple aryl halides and alkenyl halides. Adding Bu4NI into the system can reduce the dehalogenation side reaction of the substrate. A series of α, G, G- trisubstituted butyrolactone products were successfully synthesized by molybdenum disulfide, and the enantioselectivity reached 99% E.E.E., and the asymmetric induction of chiral proton source was realized by reagent control. Recently, isomorphic coupling and cross-coupling of chiral sulfoxide-modified imines induced by molybdenum disulfide and high enantioselective synthesis of azapinacol and aldehyde have been successfully completed, which has become a useful method to synthesize o-diamine, asymmetric o-diamine and o-amine alcohol fragments. At the same time, the high enantioselective synthesis of substituted phthalide compounds catalyzed by chiral proton source was realized for the first time.
Biocatalysis of oxidoreductase and hydroxynitrilase: Through cooperation with Professor Li Zuyi, the oxidoreductase G.38 with independent intellectual property rights was screened from soil. Its characteristics are as follows: many enzymes and yeasts reduce carbonyl groups according to Prelog rules, while G.38 not only has high activity, but also can reduce carbonyl groups to hydroxyl groups in an anti-Prelog mode; A new 6 yuan and 5 yuan bicyclic diketone synthon with parallel keratin was synthesized. It was found that the crude enzyme of hydroxycyanation catalyzed the synthesis of chiral cyanohydrin in conventional organic solvent (without organic-water buffer), and four new sources of (R)- cyanohydrin with high activity were screened out. The system has a bright future.
Up to now, * * * has published more than 50 papers 1, applied for 30 patents and granted 13 patents, among which1won the third prize of Shanghai invention patent. He has won the second prize of national scientific and technological progress 10, the first prize of scientific and technological progress of Chinese Academy of Sciences 1992, the national expert with outstanding contributions 1993, 1997, the nomination prize of Shanghai scientific and technological elite 1996, and the special prize of Zhuang Changgong of Shanghai Chemical and Chemical Society 65438.