How long is the product production cycle?
A: At present, the 2000m2GMP workshop has the capacity of producing 400,000 powders per month.
02
Probiotics have strong activity, how to understand it?
A: The World Health Organization (WHO) defines probiotics as living microorganisms that play a healthy role in the host when ingested in sufficient quantities. Our products can resist gastric acid and choline by microcapsule multilayer embedding technology, so that live bacteria can easily reach the intestinal colonization point to release and proliferate, thus regulating the intestinal microecological balance.
03
What advantages do you have compared with similar products on the market?
A: First of all, our strain has advantages:
1, Lactobacillus salivarius Li0 1 was selected by Weileshu, which is the result of scientific research transformation in Zhejiang University. It can secrete enterococcus-specific antibacterial peptides, antagonize staphylococcus through specific nutritional competition, and inhibit the growth of Candida albicans through secretion;
2. Lactobacillus helveticus R-52 is imported from France, which can maintain the intestinal barrier function, control the transfer of pathogenic bacteria, inhibit the attachment of intestinal pathogenic bacteria and improve immunity;
3. Bifidobacterium longum R 175 is imported from France. The first batch of bacteria implanted into the sterile digestive tract of newborns is the dominant bacteria for breast-feeding infants, which can enhance the intestinal barrier function, prevent the transfer of infectious factors, inhibit the growth and adhesion of pathogenic bacteria, and produce specific or non-specific immunity. ?
(From the literature: Screening of Lactobacillus salivarius and Preliminary Study on Its Antimicrobial Substances "Oral Medicine Research"
High quality draft genome sequence of Streptococcus corni subspecies. cohni istrin Hu-0 1《Stand。
Genome science. 20 14]
Research progress on probiotic function and application of Lactobacillus helveticus
Therapeutic effect of different doses of Bifidobacterium longum on antibiotic-induced intestinal flora imbalance in rats
Effect of preventing antibiotic-associated diarrhea: a prospective, randomized, double-blind, multicenter research journal of Korean medical science.
Interaction between Lactic Acid Bacteria and Human Intestinal Epithelial Cells: Effect on Cytokine Production (Journal of Food Protection).
Secondly, our formula has advantages: using patented strains and French imported strains, adding prebiotics (fructooligosaccharides, inulin) formula, regulating intestinal flora and improving host health.
In addition, our technology also has advantages: using patented microcapsule technology, preparing microcapsules with nano-materials as packaging materials, which can actively embed probiotics and put "protective clothing" on probiotics. Effectively improve the survival rate of probiotics during long-term preservation and gastrointestinal targeted delivery. The acid resistance is improved to more than 1000 times that of common probiotics; In addition, it has a strong anti-bile ability, can resist bile erosion in the intestine, and is easy to reach the intestinal colonization point for release and proliferation, and the survival rate is greatly improved.
At the same time, it ensures that the strain can still maintain its activity at room temperature, can be carried around without refrigeration, and is convenient to eat, while the natural brittleness of common probiotics requires short-term storage at 4℃.
Our products have participated in many national major special projects and national natural projects;
1, national natural science foundation project-randomized controlled multicenter study of probiotics combined with prebiotics in the treatment of PBC patients (project approval number 8 1790634, registration number of China clinical trial center: ChiCTR 19000245 17).
2. Research project under the "Thirteenth Five-Year Plan" major national science and technology project "Study on comprehensive prevention and intervention technology and new strategies for hepatitis B" (No.:2017zx1021): "Multi-center research on intestinal microecological intervention technology scheme for different progression risks of hepatitis B" (No.:2065438)
3. The national key research and development plan "Study on the relationship and mechanism between intestinal microecological changes and aging of intestinal brain axis" (project number 20 18YFC2000503).
04
What are the advanced technologies and technologies of the products?
A: We adopt the patented technology of microencapsulation and multi-layer embedding, which can actively embed probiotics and put "protective clothing" on them.
The acid resistance is improved to more than 1000 times that of common probiotics; In addition, it also has a strong anti-bile ability, which can resist the erosion of bile on the intestine. Easily reach the intestinal colonization point, release proliferation, and greatly improve the survival rate.
At the same time, it ensures that the strain keeps its activity at room temperature, can be carried around without refrigeration, and is convenient to eat. However, the natural brittleness of common probiotics requires short-term storage at 4℃.