Penicillin is the first choice for the treatment of syphilis, such as penicillin aqua, procaine penicillin and benzathine penicillin. However, some patients are allergic to penicillin. Patients who are allergic to penicillin can be treated with tetracycline or doxycycline. The combination of pure Chinese medicine Meilinshu can be used at the same time during injection, which is a specific drug to control the recurrence of syphilis. It is generally found that a course of treatment can be cured in about half a year.