Later, I gradually realized that the surface energy of spherical glass magnifies the image of an object.
In 1590, Dutch and Italian glasses manufacturers have built magnifying instruments similar to microscopes.
16 1 1 year Kepler: The manufacturing method of compound microscope is put forward.
Hooke (1665): The origin of the word "cell" was obtained by Hooke's observation of tiny stomata in plant cork tissue with a compound microscope.
1674 Levin Hook: After the publication of the protozoology report, he became the first person to discover the existence of "bacteria" nine years later.
Brown (1833): Observe violets under the microscope, and then give his detailed discussion on the nucleus.
1838 Schleiden and Shi Wan (Schleiden and Wang Shi): Both of them advocate the principle of cytology, and their main idea is that nucleated cells are the basic elements of all animal and plant tissues and functions.
1857 Kolliker: Mitochondria were found in muscle cells.
1876 Abbe (ABI): Analyze the diffraction phenomenon when the image is imaged under the microscope, and try to design the most ideal microscope.
1879 Flrmming (Fleming): It is found that when an animal cell is undergoing mitosis, its chromosome activity is clearly visible.
188 1 year Retziue (Ruizu): The animal organization report has come out, and no one can surpass this publication at present.
However, 20 years later, a group of histologists led by Cahal developed the microscopic staining observation method, which laid the foundation for the future microscopic anatomy.
1882 Koch (Kirk): He dyed microbial tissues with benzene dye and found cholera and mycobacterium tuberculosis.
In the next 20 years, other bacteriologists, such as Kleber and Pasteur (Klebel and Pasteur), confirmed the causes of many diseases by examining the staining drugs under the microscope.
1886 Zeiss: Breaking the limitation of general visible light theory, his invention-Abbey Type and a series of lenses opened up a new world for microscopists to interpret images.
1898 Golgi: the first microscopist to find Golgi in bacteria.
He used silver nitrate to dye cells, which made a big step in the study of human cells.
Lacassagne (1924): He and his experimental partner * * * jointly developed a radiographic method. The invention uses radioactive polonium to detect biological specimens.
1930 Lebedev: Design and match the first interference microscope.
In addition, zernike invented the phase difference microscope in 1932, and the phase difference observer developed by them expanded the traditional optical microscope, enabling biologists to observe various details on stained living cells.
194 1 year Kuhns (Quincy's): fluorescent dye was added to antibody to detect cell antigen.
Normaski (1952): invented the interference phase difference optical system.
This invention is not only patented, but also named after the inventor himself.
198 1 year Allen and Inoue (Allen and Ainiu): The image enhancement and contrast in the principle of optical microscope tend to be perfect.
Confocal scanning microscope (* * *) is widely used in the market.